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• W2132768644 startingPage "55" @default.
• W2132768644 abstract "We have studied the effect of increasing concentrations of isoflurane on high- and low-affinity uptake of L-glutamate using synaptosomes from rat cerebral cortex. In the high-affinity uptake range, 0.5% isoflurane had no effect on uptake velocity, while 1.5% and 3.0% isoflurane caused an increase in mean Vmax to 131 (SEM 54) and 210 (103)% of control, respectively. There was no significant change in the K(m) value. Vmax and K(m) values for low-affinity uptake of L-glutamate were unchanged by 1.5% isoflurane. These results provide evidence for an isoflurane-induced increase in high-affinity uptake of glutamate into presynaptic terminals. This effect may contribute to a reduction of transmitter in the synaptic cleft and thereby decreased excitatory synaptic transmission." @default.
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• W2132768644 date "1997-01-01" @default.
• W2132768644 modified "2023-10-01" @default.
• W2132768644 title "Isoflurane increases the uptake of glutamate in synaptosomes from rat cerebral cortex" @default.
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• W2132768644 doi "https://doi.org/10.1093/bja/78.1.55" @default.
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