Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132771554> ?p ?o ?g. }
- W2132771554 endingPage "7384" @default.
- W2132771554 startingPage "7379" @default.
- W2132771554 abstract "Professional APC play a central role in generating antiviral CD8(+) CTL immunity. However, the fate of such APC following interaction with these same CTL remains poorly understood. We have shown previously that prolonged Ag presentation persists in the presence of a strong CTL response following HSV infection. In this study, we examined the mechanism of survival of APC in vivo when presenting an immunodominant determinant from HSV. We show that transferred peptide-labeled dendritic cells were eliminated from draining lymph nodes in the presence of HSV-specific CTL. Maturation of dendritic cells with LPS or anti-CD40 before injection protected against CTL lysis in vivo. Furthermore, endogenous APC could be eliminated from draining lymph nodes early after HSV infection by adoptive transfer of HSV-specific CTL, yet the cotransfer of significant virus-specific CD4(+) T cell help promoted prolonged Ag presentation. This suggests that Th cells may assist in prolonging class I-restricted Ag presentation, potentially enhancing CTL recruitment and allowing more efficient T cell priming." @default.
- W2132771554 created "2016-06-24" @default.
- W2132771554 creator A5016350097 @default.
- W2132771554 creator A5018173229 @default.
- W2132771554 creator A5023657886 @default.
- W2132771554 creator A5037574752 @default.
- W2132771554 creator A5038103278 @default.
- W2132771554 creator A5066955897 @default.
- W2132771554 date "2006-06-15" @default.
- W2132771554 modified "2023-10-14" @default.
- W2132771554 title "CD4+ T Cells Can Protect APC from CTL-Mediated Elimination" @default.
- W2132771554 cites W1482806584 @default.
- W2132771554 cites W1482928030 @default.
- W2132771554 cites W1501518736 @default.
- W2132771554 cites W1521443135 @default.
- W2132771554 cites W1617728256 @default.
- W2132771554 cites W1678167583 @default.
- W2132771554 cites W1917000450 @default.
- W2132771554 cites W1928874882 @default.
- W2132771554 cites W1939038633 @default.
- W2132771554 cites W1959677146 @default.
- W2132771554 cites W1973107648 @default.
- W2132771554 cites W2013167047 @default.
- W2132771554 cites W2022306056 @default.
- W2132771554 cites W2027238003 @default.
- W2132771554 cites W2031778684 @default.
- W2132771554 cites W2033252167 @default.
- W2132771554 cites W2048784307 @default.
- W2132771554 cites W2055875542 @default.
- W2132771554 cites W2056924500 @default.
- W2132771554 cites W2071969437 @default.
- W2132771554 cites W2087047374 @default.
- W2132771554 cites W2101686230 @default.
- W2132771554 cites W2105895969 @default.
- W2132771554 cites W2108981460 @default.
- W2132771554 cites W2109487161 @default.
- W2132771554 cites W2112296339 @default.
- W2132771554 cites W2112643590 @default.
- W2132771554 cites W2115136218 @default.
- W2132771554 cites W2122013117 @default.
- W2132771554 cites W2123448680 @default.
- W2132771554 cites W2125490051 @default.
- W2132771554 cites W2126258731 @default.
- W2132771554 cites W2133431461 @default.
- W2132771554 cites W2138842591 @default.
- W2132771554 cites W2139412010 @default.
- W2132771554 cites W2155561731 @default.
- W2132771554 cites W2163351493 @default.
- W2132771554 cites W2886274086 @default.
- W2132771554 cites W4313331452 @default.
- W2132771554 doi "https://doi.org/10.4049/jimmunol.176.12.7379" @default.
- W2132771554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16751382" @default.
- W2132771554 hasPublicationYear "2006" @default.
- W2132771554 type Work @default.
- W2132771554 sameAs 2132771554 @default.
- W2132771554 citedByCount "38" @default.
- W2132771554 countsByYear W21327715542012 @default.
- W2132771554 countsByYear W21327715542013 @default.
- W2132771554 countsByYear W21327715542014 @default.
- W2132771554 countsByYear W21327715542016 @default.
- W2132771554 countsByYear W21327715542019 @default.
- W2132771554 countsByYear W21327715542020 @default.
- W2132771554 countsByYear W21327715542022 @default.
- W2132771554 countsByYear W21327715542023 @default.
- W2132771554 crossrefType "journal-article" @default.
- W2132771554 hasAuthorship W2132771554A5016350097 @default.
- W2132771554 hasAuthorship W2132771554A5018173229 @default.
- W2132771554 hasAuthorship W2132771554A5023657886 @default.
- W2132771554 hasAuthorship W2132771554A5037574752 @default.
- W2132771554 hasAuthorship W2132771554A5038103278 @default.
- W2132771554 hasAuthorship W2132771554A5066955897 @default.
- W2132771554 hasBestOaLocation W21327715541 @default.
- W2132771554 hasConcept C100701293 @default.
- W2132771554 hasConcept C147969180 @default.
- W2132771554 hasConcept C154317977 @default.
- W2132771554 hasConcept C159047783 @default.
- W2132771554 hasConcept C167672396 @default.
- W2132771554 hasConcept C202751555 @default.
- W2132771554 hasConcept C203014093 @default.
- W2132771554 hasConcept C2776090121 @default.
- W2132771554 hasConcept C55493867 @default.
- W2132771554 hasConcept C59822182 @default.
- W2132771554 hasConcept C81444415 @default.
- W2132771554 hasConcept C83464605 @default.
- W2132771554 hasConcept C86803240 @default.
- W2132771554 hasConcept C8891405 @default.
- W2132771554 hasConcept C90375314 @default.
- W2132771554 hasConceptScore W2132771554C100701293 @default.
- W2132771554 hasConceptScore W2132771554C147969180 @default.
- W2132771554 hasConceptScore W2132771554C154317977 @default.
- W2132771554 hasConceptScore W2132771554C159047783 @default.
- W2132771554 hasConceptScore W2132771554C167672396 @default.
- W2132771554 hasConceptScore W2132771554C202751555 @default.
- W2132771554 hasConceptScore W2132771554C203014093 @default.
- W2132771554 hasConceptScore W2132771554C2776090121 @default.
- W2132771554 hasConceptScore W2132771554C55493867 @default.
- W2132771554 hasConceptScore W2132771554C59822182 @default.
- W2132771554 hasConceptScore W2132771554C81444415 @default.