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- W2132779894 abstract "Primary anti-NP [(4-hydroxy-3-nitrophenyl)acetyl] antibodies and NP-specific receptors isolated from T cells of mice carrying the Ig-1b allotype express the NPb idio-type and a fine specificity marker (heteroclicity) which are both controlled by V genes in the heavy chain linkage group. While in antibodies both markers are invariably expressed in association with Ig light chains of the Λ type, antigen-binding T cell-derived receptors appear not to follow this rule in that they do not significantly bind to anti-Λ antisera. Mice of the SJL strain also carry the Ig-lb allotype but express a defect in Λ chain synthesis, and their primary anti-NP response is thus almost completely devoid of Λ-bearing heteroclitic molecules of the NPb idiotype. In contrast, both NPb idiotype and heteroclicity are expressed in the majority of T cell-derived receptors. This result permits a positive discrimination between T cell-derived receptors and humoral antibodies in the SJL strain and shows that V gene expression follows different rules in the T and the B cell compartment. The expression of Ig V regions in isolated T cell-derived receptors was also analyzed with antisera binding to presumed “framework” determinants of the VH and the VΛdomains of Ig. A reaction of anti-VH antiserum with isolated T cell receptors could clearly be demonstrated. The anti-VΛ antiserum may bind to a minor fraction of the NP-specific molecules in our T cell receptor preparations." @default.
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- W2132779894 date "1979-04-01" @default.
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- W2132779894 title "Isolated hapten-binding receptors of sensitized lymphocytes. IV. Expression of immimoglobulin variable regions in (4-hydroxy-3-nitrophenyl) acetyl (NP)-specific receptors isolated from murine B and T lymphocytes" @default.
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- W2132779894 doi "https://doi.org/10.1002/eji.1830090415" @default.
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