Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132811637> ?p ?o ?g. }
- W2132811637 endingPage "326" @default.
- W2132811637 startingPage "317" @default.
- W2132811637 abstract "Dendritic cells (DC) are key regulators of the immune system, which is compromised in patients with bipolar disorder. We sought to study monocyte-derived DC in bipolar disorder.Monocytes purified from blood collected from DSM-IV bipolar disorder outpatients (n = 53, 12 without lithium treatment) and healthy individuals (n = 34) were differentiated into DC via standard granulocyte-macrophpage colony-stimulating factor/interleukin-4 culture (with/without 1, 5, and 10 mmol/L lithium chloride). The DC were analyzed for DC-specific and functional markers and for T-cell stimulatory potency.Monocytes of bipolar patients showed a mild hampering in their differentiation into fully active DC, showing a weak residual expression of the monocyte marker CD14 and a relatively low potency to stimulate autologous T cells. Lithium treatment abolished this mild defect, and monocyte-derived DC of treated bipolar patients showed signs of activation (i.e., an up-regulated potency to stimulate autologous T cells and a higher expression of the DC-specific marker CD1a). This activated phenotype contrasted with the suppressed phenotype of monocyte-derived DC exposed to lithium in vitro (10 mmol/L) during culture.Dendritic cells show mild aberrancies in bipolar disorder that are fully restored to even activation after in vivo lithium treatment." @default.
- W2132811637 created "2016-06-24" @default.
- W2132811637 creator A5005922558 @default.
- W2132811637 creator A5008103327 @default.
- W2132811637 creator A5041793132 @default.
- W2132811637 creator A5041869844 @default.
- W2132811637 creator A5083679801 @default.
- W2132811637 creator A5086507457 @default.
- W2132811637 creator A5090383836 @default.
- W2132811637 creator A5090875089 @default.
- W2132811637 date "2006-02-01" @default.
- W2132811637 modified "2023-09-25" @default.
- W2132811637 title "Monocyte-Derived Dendritic Cells in Bipolar Disorder" @default.
- W2132811637 cites W1661544713 @default.
- W2132811637 cites W1667550729 @default.
- W2132811637 cites W1966882977 @default.
- W2132811637 cites W1977945339 @default.
- W2132811637 cites W1983927699 @default.
- W2132811637 cites W1993490510 @default.
- W2132811637 cites W1994236522 @default.
- W2132811637 cites W1995623538 @default.
- W2132811637 cites W1998776723 @default.
- W2132811637 cites W2000171400 @default.
- W2132811637 cites W2006498696 @default.
- W2132811637 cites W2010493158 @default.
- W2132811637 cites W2018302367 @default.
- W2132811637 cites W2020428096 @default.
- W2132811637 cites W2022669082 @default.
- W2132811637 cites W2030034545 @default.
- W2132811637 cites W2032657270 @default.
- W2132811637 cites W2035712460 @default.
- W2132811637 cites W2047073144 @default.
- W2132811637 cites W2053067715 @default.
- W2132811637 cites W2053221584 @default.
- W2132811637 cites W2054492621 @default.
- W2132811637 cites W2055476558 @default.
- W2132811637 cites W2056780460 @default.
- W2132811637 cites W2059467700 @default.
- W2132811637 cites W2060345189 @default.
- W2132811637 cites W2069782517 @default.
- W2132811637 cites W2089760657 @default.
- W2132811637 cites W2090291829 @default.
- W2132811637 cites W2091907699 @default.
- W2132811637 cites W2110964571 @default.
- W2132811637 cites W2111220263 @default.
- W2132811637 cites W2111837231 @default.
- W2132811637 cites W2116369972 @default.
- W2132811637 cites W2116994483 @default.
- W2132811637 cites W2122182618 @default.
- W2132811637 cites W2127124395 @default.
- W2132811637 cites W2128277870 @default.
- W2132811637 cites W2131761283 @default.
- W2132811637 cites W2131826740 @default.
- W2132811637 cites W2144413848 @default.
- W2132811637 cites W2167659819 @default.
- W2132811637 cites W2627728 @default.
- W2132811637 doi "https://doi.org/10.1016/j.biopsych.2005.06.041" @default.
- W2132811637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16165108" @default.
- W2132811637 hasPublicationYear "2006" @default.
- W2132811637 type Work @default.
- W2132811637 sameAs 2132811637 @default.
- W2132811637 citedByCount "37" @default.
- W2132811637 countsByYear W21328116372012 @default.
- W2132811637 countsByYear W21328116372013 @default.
- W2132811637 countsByYear W21328116372014 @default.
- W2132811637 countsByYear W21328116372015 @default.
- W2132811637 countsByYear W21328116372016 @default.
- W2132811637 countsByYear W21328116372017 @default.
- W2132811637 countsByYear W21328116372018 @default.
- W2132811637 countsByYear W21328116372019 @default.
- W2132811637 countsByYear W21328116372021 @default.
- W2132811637 countsByYear W21328116372022 @default.
- W2132811637 countsByYear W21328116372023 @default.
- W2132811637 crossrefType "journal-article" @default.
- W2132811637 hasAuthorship W2132811637A5005922558 @default.
- W2132811637 hasAuthorship W2132811637A5008103327 @default.
- W2132811637 hasAuthorship W2132811637A5041793132 @default.
- W2132811637 hasAuthorship W2132811637A5041869844 @default.
- W2132811637 hasAuthorship W2132811637A5083679801 @default.
- W2132811637 hasAuthorship W2132811637A5086507457 @default.
- W2132811637 hasAuthorship W2132811637A5090383836 @default.
- W2132811637 hasAuthorship W2132811637A5090875089 @default.
- W2132811637 hasConcept C126322002 @default.
- W2132811637 hasConcept C153911025 @default.
- W2132811637 hasConcept C185592680 @default.
- W2132811637 hasConcept C202751555 @default.
- W2132811637 hasConcept C203014093 @default.
- W2132811637 hasConcept C2776174506 @default.
- W2132811637 hasConcept C2778170410 @default.
- W2132811637 hasConcept C2778513237 @default.
- W2132811637 hasConcept C2778541603 @default.
- W2132811637 hasConcept C2781184567 @default.
- W2132811637 hasConcept C502942594 @default.
- W2132811637 hasConcept C55493867 @default.
- W2132811637 hasConcept C57992300 @default.
- W2132811637 hasConcept C71924100 @default.
- W2132811637 hasConcept C86803240 @default.
- W2132811637 hasConcept C8891405 @default.