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• W2132827639 abstract "A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (<10 nM) in both enzymatic and cellular assays. Further characterization of inhibitor 2 indicated that this analog possessed excellent in vivo potency (ED50 2.1 mg/kg) as measured in an estradiol-induced mouse uterine edema model." @default.
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• W2132827639 date "2007-03-01" @default.
• W2132827639 modified "2023-10-16" @default.
• W2132827639 title "Thienopyridine urea inhibitors of KDR kinase" @default.
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• W2132827639 doi "https://doi.org/10.1016/j.bmcl.2006.12.015" @default.
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