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- W2132841618 abstract "AbstractPhysiological changes in coagulation factors during pregnancy are important to minimise blood loss during gestation and delivery, but may also lead to a 4–6 fold increased risk of venous thromboembolism during pregnancy and after delivery. Approximately 25% of maternal mortality can be ascribed to thromboembolism if untreated, while this figure is reduced to less than 1% when diagnosed on time. Clinical diagnosis is complicated by the fact that the symptoms associated with venous thrombosis are relatively common complaints of pregnant women. A rapid genetic test has been developed for simultaneous detection of the most common genetic risk factors associated with thrombophilia, the factor V 1691GA (Leiden) and prothrombin 20210GA mutations. Mutation 677CT in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which increases homocysteine levels by 15–25% when two copies of the T-allele is present, is also included as part of this “prenatal care genetic test”. Hyperhomocysteinaemia has been a..." @default.
- W2132841618 created "2016-06-24" @default.
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- W2132841618 date "2005-08-01" @default.
- W2132841618 modified "2023-09-25" @default.
- W2132841618 title "Rapid thrombophilia genetic test facilitates improved prenatal care for mother and child" @default.
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- W2132841618 doi "https://doi.org/10.1080/20786204.2005.10873264" @default.
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