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- W2132867079 abstract "Psychological stress contributes to the development of clinical depression. This has prompted many preclinical studies to investigate the neurobiology of this relationship, however, the effects of stress on glia remain unclear. In this study, we wished to determine, first, how exposure to chronic psychological stress affects microglial activity within the prefrontal cortex (PFC) and, second, whether the observed changes were meaningfully related to corresponding changes in local neuronal activity and PFC-regulated behavior. Therefore, we examined markers of microglial activation, antigen presentation, apoptosis, and persistent neuronal activation within the PFC after exposure to repeated restraint stress. We also examined the effect of stress on spatial working memory, a PFC-dependent function. Finally, we tested the ability of a microglial activation inhibitor (minocycline) to alter the impact of chronic stress on all of these endpoints. Stressor exposure produced positively correlated increases in microglial and long-term neuronal activation in the PFC but not antigen presentation or apoptosis. As expected, it also impaired spatial working memory. Importantly, minocycline reduced the impact of stress on neuronal activation and working memory, as well as microglial activation. These results suggest a role for microglia in mediating the effects of stress on PFC neuronal function and PFC-regulated behavior." @default.
- W2132867079 created "2016-06-24" @default.
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- W2132867079 creator A5051710706 @default.
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- W2132867079 creator A5091875410 @default.
- W2132867079 date "2011-08-30" @default.
- W2132867079 modified "2023-10-06" @default.
- W2132867079 title "Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex" @default.
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- W2132867079 doi "https://doi.org/10.1093/cercor/bhr229" @default.
- W2132867079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21878486" @default.
- W2132867079 hasPublicationYear "2011" @default.
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