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- W2132887925 abstract "Dopaminergic therapy to relieve motor manifestations of idiopathic Parkinson’s disease may inadvertently cause inappropriate hypersexuality (Vilas et al., 2012). Impulse control disorders that include gambling, eating and hypersexuality seem to occur more commonly with dopamine receptor agonist therapy than l-DOPA and can lead to substantial morbidity with social, psychological and legal consequences (Vilas et al., 2012). The unregulated nature of direct dopamine receptor activation may provide potential clues to the underlying mechanisms. However, the pathophysiological basis for these behaviours remains unknown. Interestingly, dopaminergic pathways also play a key role in brain networks involved in the reward system, and pathological responses in this system may underlie addiction (Volkow et al., 2012). Similarities between addictive behaviour and drug-induced hypersexuality in Parkinson’s disease suggest that they may share common pathological brain mechanisms. Thus investigations of brain regions and networks related to dopaminergic-induced hypersexuality in Parkinson’s disease could shed light on these potentially common underlying mechanisms and provide clues for rationale treatment. The study by Politis et al. (2013) in this issue of Brain takes an important step in this direction.Impulse control disorders including pathological gambling and eating, compulsive shopping and hypersexuality, as well as the dopamine dysregulation syndrome have been described in the context of dopaminergic therapy for Parkinson’s disease (Vilas et al., 2012). Similarly, dopaminergic neurotransmission has been linked to …" @default.
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- W2132887925 date "2013-02-01" @default.
- W2132887925 modified "2023-09-23" @default.
- W2132887925 title "Sex, drugs and Parkinson’s disease" @default.
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- W2132887925 doi "https://doi.org/10.1093/brain/awt022" @default.
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