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• W2132910200 abstract "Alterations in the glucose tolerance test (GTT) and mineral balance of healthy, nonobese subjects were studied during periods of fasting, during refeeding, and while on a 500-kcal diet. Fasting for 48 hr produced an abnormal GTT that progressed in severity as fasts were prolonged to 72 and 96 hr. During fasting, a significant diurnal variation was observed for plasma free fatty acids and phosphate but not for plasma glucose, sodium, potassium, calcium, or chloride. During refeeding over a 6-day period, the GTT was significantly abnormal on day 1 but not on day 2 or 3. On days 4 to 6, a significant deterioration in the GTT was observed for each of the subjects studied. During the 5th day of refeeding a significant natriuresis developed, which was accompanied by a significant increase in urine volume and reduction in water intake. Thus, the deterioration of the GTT during refeeding occurred concomitantly with a marked alteration in body fluid and electrolyte balance. Our studies demonstrate that a 500-kcal diet containing 85 g sucrose/day maintains a normal GTT in normal subjects over a 10-day period of study. Other studies indicate, however, that a low carbohydrate diet may lead to deterioration of the GTT in patients with alterations of carbohydrate homeostasis." @default.
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• W2132910200 date "1972-01-01" @default.
• W2132910200 modified "2023-09-25" @default.
• W2132910200 title "Effect of fasting, caloric restriction, and refeeding on glucose tolerance of normal men" @default.
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• W2132910200 doi "https://doi.org/10.1093/ajcn/25.1.41" @default.
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