Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132922923> ?p ?o ?g. }
- W2132922923 endingPage "363" @default.
- W2132922923 startingPage "356" @default.
- W2132922923 abstract "Approximately 50% of the world's population is infected with Helicobacter pylori, leading to chronic inflammation, which increases the risk for gastric adenocarcinoma. MyD88 is a key adaptor molecule in inflammatory pathways involved in interleukin 1 (IL-1)/IL-18/Toll-like receptor signaling and has been shown to have divergent effects in carcinogenesis. The role of MyD88 in Helicobacter-induced gastric malignancy is unknown. Using a mouse model of Helicobacter-induced gastric cancer, we assessed the role of MyD88 in cancer development by evaluating gastric histopathology, apoptosis, proliferation, and cytokine expression. Infection of MyD88-deficient (Myd88(-/-)) mice with Helicobacter resulted in early and rapid advancement to gastric dysplasia as early as 25 weeks postinfection. The progression of Helicobacter-induced disease to precancerous and cancerous lesions in the absence of MyD88 signaling was accompanied by increased gastric epithelial apoptosis and proliferation. In addition, inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), IL-6, and IL-1β were highly expressed in association with the development of gastric dysplasia. These data suggest that MyD88 signaling retards development and progression to cancer during Helicobacter infection. This is the first study to show evidence of MyD88 protection in an infection-driven inflammation-associated cancer model." @default.
- W2132922923 created "2016-06-24" @default.
- W2132922923 creator A5004545352 @default.
- W2132922923 creator A5030470781 @default.
- W2132922923 creator A5033881334 @default.
- W2132922923 creator A5058658224 @default.
- W2132922923 creator A5064694065 @default.
- W2132922923 creator A5072134548 @default.
- W2132922923 date "2014-01-01" @default.
- W2132922923 modified "2023-10-01" @default.
- W2132922923 title "Deficiency of the Myeloid Differentiation Primary Response Molecule MyD88 Leads to an Early and Rapid Development of Helicobacter-Induced Gastric Malignancy" @default.
- W2132922923 cites W1696233391 @default.
- W2132922923 cites W1902241237 @default.
- W2132922923 cites W1965037168 @default.
- W2132922923 cites W1969980017 @default.
- W2132922923 cites W1972597448 @default.
- W2132922923 cites W1980460625 @default.
- W2132922923 cites W1984744520 @default.
- W2132922923 cites W1995787460 @default.
- W2132922923 cites W2001320403 @default.
- W2132922923 cites W2004465286 @default.
- W2132922923 cites W2005884645 @default.
- W2132922923 cites W2006439698 @default.
- W2132922923 cites W2006471464 @default.
- W2132922923 cites W2008631743 @default.
- W2132922923 cites W2027931900 @default.
- W2132922923 cites W2029912020 @default.
- W2132922923 cites W2031823238 @default.
- W2132922923 cites W2034269086 @default.
- W2132922923 cites W2039845199 @default.
- W2132922923 cites W2041931160 @default.
- W2132922923 cites W2046454404 @default.
- W2132922923 cites W2059574805 @default.
- W2132922923 cites W2083089709 @default.
- W2132922923 cites W2087696426 @default.
- W2132922923 cites W2090241102 @default.
- W2132922923 cites W2095495335 @default.
- W2132922923 cites W2099198955 @default.
- W2132922923 cites W2101363646 @default.
- W2132922923 cites W2102144390 @default.
- W2132922923 cites W2103423744 @default.
- W2132922923 cites W2106787323 @default.
- W2132922923 cites W2115528382 @default.
- W2132922923 cites W2116554142 @default.
- W2132922923 cites W2118983602 @default.
- W2132922923 cites W2131861368 @default.
- W2132922923 cites W2137257146 @default.
- W2132922923 cites W2153042210 @default.
- W2132922923 cites W2161722637 @default.
- W2132922923 cites W4246077736 @default.
- W2132922923 doi "https://doi.org/10.1128/iai.01344-13" @default.
- W2132922923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911874" @default.
- W2132922923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24166959" @default.
- W2132922923 hasPublicationYear "2014" @default.
- W2132922923 type Work @default.
- W2132922923 sameAs 2132922923 @default.
- W2132922923 citedByCount "32" @default.
- W2132922923 countsByYear W21329229232014 @default.
- W2132922923 countsByYear W21329229232015 @default.
- W2132922923 countsByYear W21329229232016 @default.
- W2132922923 countsByYear W21329229232017 @default.
- W2132922923 countsByYear W21329229232018 @default.
- W2132922923 countsByYear W21329229232019 @default.
- W2132922923 countsByYear W21329229232020 @default.
- W2132922923 countsByYear W21329229232021 @default.
- W2132922923 countsByYear W21329229232022 @default.
- W2132922923 countsByYear W21329229232023 @default.
- W2132922923 crossrefType "journal-article" @default.
- W2132922923 hasAuthorship W2132922923A5004545352 @default.
- W2132922923 hasAuthorship W2132922923A5030470781 @default.
- W2132922923 hasAuthorship W2132922923A5033881334 @default.
- W2132922923 hasAuthorship W2132922923A5058658224 @default.
- W2132922923 hasAuthorship W2132922923A5064694065 @default.
- W2132922923 hasAuthorship W2132922923A5072134548 @default.
- W2132922923 hasBestOaLocation W21329229231 @default.
- W2132922923 hasConcept C121608353 @default.
- W2132922923 hasConcept C203014093 @default.
- W2132922923 hasConcept C2776409635 @default.
- W2132922923 hasConcept C2776914184 @default.
- W2132922923 hasConcept C2778690821 @default.
- W2132922923 hasConcept C2779399171 @default.
- W2132922923 hasConcept C2780832600 @default.
- W2132922923 hasConcept C2908647359 @default.
- W2132922923 hasConcept C502942594 @default.
- W2132922923 hasConcept C54355233 @default.
- W2132922923 hasConcept C555283112 @default.
- W2132922923 hasConcept C71924100 @default.
- W2132922923 hasConcept C86803240 @default.
- W2132922923 hasConcept C99454951 @default.
- W2132922923 hasConceptScore W2132922923C121608353 @default.
- W2132922923 hasConceptScore W2132922923C203014093 @default.
- W2132922923 hasConceptScore W2132922923C2776409635 @default.
- W2132922923 hasConceptScore W2132922923C2776914184 @default.
- W2132922923 hasConceptScore W2132922923C2778690821 @default.
- W2132922923 hasConceptScore W2132922923C2779399171 @default.
- W2132922923 hasConceptScore W2132922923C2780832600 @default.
- W2132922923 hasConceptScore W2132922923C2908647359 @default.
- W2132922923 hasConceptScore W2132922923C502942594 @default.