Matches in SemOpenAlex for { <https://semopenalex.org/work/W2132923611> ?p ?o ?g. }
- W2132923611 endingPage "139" @default.
- W2132923611 startingPage "128" @default.
- W2132923611 abstract "Kruppel-like factor 5 (Klf5) is a transcription factor expressed by embryonic endodermal progenitors that form the lining of the gastrointestinal tract. A Klf5 floxed allele was efficiently deleted from the intestinal epithelium by a Cre transgene under control of the Shh promoter resulting in the inhibition of villus morphogenesis and epithelial differentiation. Although proliferation of the intestinal epithelium was maintained, the expression of Elf3, Pparγ, Atoh1, Ascl2, Neurog3, Hnf4α, Cdx1, and other genes associated with epithelial cell differentiation was inhibited in the Klf5-deficient intestines. At E18.5, Klf5Δ/Δ fetuses lacked the apical brush border characteristic of enterocytes, and a loss of goblet and enteroendocrine cells was observed. The failure to form villi was not attributable to the absence of HH or PDGF signaling, known mediators of this developmental process. Klf5-deletion blocked the decrease in FoxA1 and Sox9 expression that accompanies normal villus morphogenesis. KLF5 directly inhibited activity of the FoxA1 promoter, and in turn FOXA1 inhibited Elf3 gene expression in vitro, linking the observed loss of Elf3 with the persistent expression of FoxA1 observed in Klf5-deficient mice. Genetic network analysis identified KLF5 as a key transcription factor regulating intestinal cell differentiation and cell adhesion. These studies indicate a novel requirement for KLF5 to initiate morphogenesis of the early endoderm into a compartmentalized intestinal epithelium comprised of villi and terminally differentiated cells." @default.
- W2132923611 created "2016-06-24" @default.
- W2132923611 creator A5001813162 @default.
- W2132923611 creator A5005835095 @default.
- W2132923611 creator A5011725391 @default.
- W2132923611 creator A5024094891 @default.
- W2132923611 creator A5040126408 @default.
- W2132923611 creator A5055564924 @default.
- W2132923611 creator A5059286797 @default.
- W2132923611 date "2013-03-01" @default.
- W2132923611 modified "2023-10-14" @default.
- W2132923611 title "Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium" @default.
- W2132923611 cites W1698663755 @default.
- W2132923611 cites W1978855024 @default.
- W2132923611 cites W1979165357 @default.
- W2132923611 cites W1980022034 @default.
- W2132923611 cites W1989193425 @default.
- W2132923611 cites W1996060670 @default.
- W2132923611 cites W2007014854 @default.
- W2132923611 cites W2007103545 @default.
- W2132923611 cites W2009009612 @default.
- W2132923611 cites W2011054971 @default.
- W2132923611 cites W2012095058 @default.
- W2132923611 cites W2012364448 @default.
- W2132923611 cites W2012794169 @default.
- W2132923611 cites W2017194300 @default.
- W2132923611 cites W2019874210 @default.
- W2132923611 cites W2023554450 @default.
- W2132923611 cites W2029816716 @default.
- W2132923611 cites W2032838132 @default.
- W2132923611 cites W2034303563 @default.
- W2132923611 cites W2034653929 @default.
- W2132923611 cites W2034841786 @default.
- W2132923611 cites W2036151524 @default.
- W2132923611 cites W2036228374 @default.
- W2132923611 cites W2043861102 @default.
- W2132923611 cites W2054810829 @default.
- W2132923611 cites W2064190744 @default.
- W2132923611 cites W2065053198 @default.
- W2132923611 cites W2067922543 @default.
- W2132923611 cites W2070578076 @default.
- W2132923611 cites W2071012973 @default.
- W2132923611 cites W2078523840 @default.
- W2132923611 cites W2078591745 @default.
- W2132923611 cites W2079285984 @default.
- W2132923611 cites W2081427545 @default.
- W2132923611 cites W2086796983 @default.
- W2132923611 cites W2093241467 @default.
- W2132923611 cites W2099444378 @default.
- W2132923611 cites W2103159925 @default.
- W2132923611 cites W2107277218 @default.
- W2132923611 cites W2113284270 @default.
- W2132923611 cites W2117597190 @default.
- W2132923611 cites W2117880439 @default.
- W2132923611 cites W2122719162 @default.
- W2132923611 cites W2124877697 @default.
- W2132923611 cites W2125305686 @default.
- W2132923611 cites W2130022782 @default.
- W2132923611 cites W2152349982 @default.
- W2132923611 cites W2154318738 @default.
- W2132923611 cites W2156941071 @default.
- W2132923611 cites W2158217645 @default.
- W2132923611 cites W2161282017 @default.
- W2132923611 cites W2163796644 @default.
- W2132923611 cites W2164479709 @default.
- W2132923611 cites W2171429729 @default.
- W2132923611 cites W2325433770 @default.
- W2132923611 cites W74777261 @default.
- W2132923611 cites W2053116954 @default.
- W2132923611 doi "https://doi.org/10.1016/j.ydbio.2012.12.010" @default.
- W2132923611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582784" @default.
- W2132923611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23266329" @default.
- W2132923611 hasPublicationYear "2013" @default.
- W2132923611 type Work @default.
- W2132923611 sameAs 2132923611 @default.
- W2132923611 citedByCount "38" @default.
- W2132923611 countsByYear W21329236112013 @default.
- W2132923611 countsByYear W21329236112014 @default.
- W2132923611 countsByYear W21329236112015 @default.
- W2132923611 countsByYear W21329236112016 @default.
- W2132923611 countsByYear W21329236112017 @default.
- W2132923611 countsByYear W21329236112019 @default.
- W2132923611 countsByYear W21329236112020 @default.
- W2132923611 countsByYear W21329236112021 @default.
- W2132923611 countsByYear W21329236112022 @default.
- W2132923611 countsByYear W21329236112023 @default.
- W2132923611 crossrefType "journal-article" @default.
- W2132923611 hasAuthorship W2132923611A5001813162 @default.
- W2132923611 hasAuthorship W2132923611A5005835095 @default.
- W2132923611 hasAuthorship W2132923611A5011725391 @default.
- W2132923611 hasAuthorship W2132923611A5024094891 @default.
- W2132923611 hasAuthorship W2132923611A5040126408 @default.
- W2132923611 hasAuthorship W2132923611A5055564924 @default.
- W2132923611 hasAuthorship W2132923611A5059286797 @default.
- W2132923611 hasBestOaLocation W21329236111 @default.
- W2132923611 hasConcept C104317684 @default.
- W2132923611 hasConcept C137620995 @default.
- W2132923611 hasConcept C145103041 @default.