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- W2132985950 endingPage "465" @default.
- W2132985950 startingPage "439" @default.
- W2132985950 abstract "Although heparin is an important and widely prescribed pharmaceutical anticoagulant, its high degree of sequence microheterogeneity and size polydispersity make molecular-level characterization challenging. Unlike nucleic acids and proteins that are biosynthesized through template-driven assembly processes, heparin and the related glycosaminoglycan heparan sulfate are actively remodeled during biosynthesis through a series of enzymatic reactions that lead to variable levels of O- and N-sulfonation and uronic acid epimers. As summarized in this review, heparin sequence information is determined through a bottom-up approach that relies on depolymerization reactions, size- and charge-based separations, and sensitive mass spectrometric and nuclear magnetic resonance experiments to determine the structural identity of component oligosaccharides. The structure-elucidation process, along with its challenges and opportunities for future analytical improvements, is reviewed and illustrated for a heparin-derived hexasaccharide." @default.
- W2132985950 created "2016-06-24" @default.
- W2132985950 creator A5009668109 @default.
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- W2132985950 creator A5037327153 @default.
- W2132985950 creator A5037830508 @default.
- W2132985950 creator A5087234332 @default.
- W2132985950 date "2011-07-19" @default.
- W2132985950 modified "2023-10-10" @default.
- W2132985950 title "Heparin Characterization: Challenges and Solutions" @default.
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