FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133011641> ?p ?o ?g. }

• W2133011641 endingPage "569" @default.
• W2133011641 startingPage "561" @default.
• W2133011641 abstract "Abstract Water reabsorption by organs such as the mammalian kidney and insect Malpighian tubule/hindgut requires a region of hypertonicity within the organ. To balance the high extracellular osmolarity, cells within these regions accumulate small organic molecules called osmolytes. These osmolytes can accumulate to a high level without toxic effects on cellular processes. Here we provide evidence consistent with the possibility that the two protein isoforms encoded by the inebriated (ine) gene, which are members of the Na+/Cl−-dependent neurotransmitter/osmolyte transporter family, perform osmolyte transport within the Malpighian tubule and hindgut. We show that ine mutants lacking both isoforms are hypersensitive to osmotic stress, which we assayed by maintaining flies on media containing NaCl, KCl, or sorbitol, and that this hypersensitivity is completely rescued by high-level ectopic expression of the ine-RB isoform. We provide evidence that this hypersensitivity represents a role for ine that is distinct from the increased neuronal excitability phenotype of ine mutants. Finally, we show that each ine genotype exhibits a “threshold” [NaCl]: long-term maintenance on NaCl-containing media above, but not below, the threshold causes lethality. Furthermore, this threshold value increases with the amount of ine activity. These data suggest that ine mutations confer osmotic stress sensitivity by preventing osmolyte accumulation within the Malpighian tubule and hindgut." @default.
• W2133011641 created "2016-06-24" @default.
• W2133011641 creator A5003643696 @default.
• W2133011641 creator A5036323780 @default.
• W2133011641 creator A5042023011 @default.
• W2133011641 creator A5042356923 @default.
• W2133011641 creator A5073054729 @default.
• W2133011641 creator A5082036083 @default.
• W2133011641 date "2002-02-01" @default.
• W2133011641 modified "2023-10-13" @default.
• W2133011641 title "The Drosophila <i>inebriated</i>-Encoded Neurotransmitter/Osmolyte Transporter: Dual Roles in the Control of Neuronal Excitability and the Osmotic Stress Response" @default.
• W2133011641 cites W1516995650 @default.
• W2133011641 cites W1547621531 @default.
• W2133011641 cites W1894576309 @default.
• W2133011641 cites W1980072739 @default.
• W2133011641 cites W1986115510 @default.
• W2133011641 cites W1995500532 @default.
• W2133011641 cites W2018435113 @default.
• W2133011641 cites W2029177775 @default.
• W2133011641 cites W2032715584 @default.
• W2133011641 cites W2044750341 @default.
• W2133011641 cites W2064166298 @default.
• W2133011641 cites W2065509427 @default.
• W2133011641 cites W2075109419 @default.
• W2133011641 cites W2079588007 @default.
• W2133011641 cites W2084271013 @default.
• W2133011641 cites W2085971550 @default.
• W2133011641 cites W2108511563 @default.
• W2133011641 cites W2110643873 @default.
• W2133011641 cites W2112225255 @default.
• W2133011641 cites W2112551261 @default.
• W2133011641 cites W2112860230 @default.
• W2133011641 cites W2145533695 @default.
• W2133011641 cites W2150488996 @default.
• W2133011641 cites W2157760396 @default.
• W2133011641 cites W2166626043 @default.
• W2133011641 cites W2277667842 @default.
• W2133011641 cites W2415535951 @default.
• W2133011641 cites W4298090388 @default.
• W2133011641 doi "https://doi.org/10.1093/genetics/160.2.561" @default.
• W2133011641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461969" @default.
• W2133011641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11861562" @default.
• W2133011641 hasPublicationYear "2002" @default.
• W2133011641 type Work @default.
• W2133011641 sameAs 2133011641 @default.
• W2133011641 citedByCount "28" @default.
• W2133011641 countsByYear W21330116412012 @default.
• W2133011641 countsByYear W21330116412013 @default.
• W2133011641 countsByYear W21330116412014 @default.
• W2133011641 countsByYear W21330116412015 @default.
• W2133011641 countsByYear W21330116412016 @default.
• W2133011641 countsByYear W21330116412018 @default.
• W2133011641 countsByYear W21330116412019 @default.
• W2133011641 countsByYear W21330116412020 @default.
• W2133011641 crossrefType "journal-article" @default.
• W2133011641 hasAuthorship W2133011641A5003643696 @default.
• W2133011641 hasAuthorship W2133011641A5036323780 @default.
• W2133011641 hasAuthorship W2133011641A5042023011 @default.
• W2133011641 hasAuthorship W2133011641A5042356923 @default.
• W2133011641 hasAuthorship W2133011641A5073054729 @default.
• W2133011641 hasAuthorship W2133011641A5082036083 @default.
• W2133011641 hasBestOaLocation W21330116412 @default.
• W2133011641 hasConcept C104317684 @default.
• W2133011641 hasConcept C120405084 @default.
• W2133011641 hasConcept C127160389 @default.
• W2133011641 hasConcept C129900496 @default.
• W2133011641 hasConcept C143065580 @default.
• W2133011641 hasConcept C149011108 @default.
• W2133011641 hasConcept C150149183 @default.
• W2133011641 hasConcept C168529131 @default.
• W2133011641 hasConcept C170493617 @default.
• W2133011641 hasConcept C173758957 @default.
• W2133011641 hasConcept C22145727 @default.
• W2133011641 hasConcept C2776219046 @default.
• W2133011641 hasConcept C2776942755 @default.
• W2133011641 hasConcept C55493867 @default.
• W2133011641 hasConcept C59822182 @default.
• W2133011641 hasConcept C86803240 @default.
• W2133011641 hasConcept C95444343 @default.
• W2133011641 hasConceptScore W2133011641C104317684 @default.
• W2133011641 hasConceptScore W2133011641C120405084 @default.
• W2133011641 hasConceptScore W2133011641C127160389 @default.
• W2133011641 hasConceptScore W2133011641C129900496 @default.
• W2133011641 hasConceptScore W2133011641C143065580 @default.
• W2133011641 hasConceptScore W2133011641C149011108 @default.
• W2133011641 hasConceptScore W2133011641C150149183 @default.
• W2133011641 hasConceptScore W2133011641C168529131 @default.
• W2133011641 hasConceptScore W2133011641C170493617 @default.
• W2133011641 hasConceptScore W2133011641C173758957 @default.
• W2133011641 hasConceptScore W2133011641C22145727 @default.
• W2133011641 hasConceptScore W2133011641C2776219046 @default.
• W2133011641 hasConceptScore W2133011641C2776942755 @default.
• W2133011641 hasConceptScore W2133011641C55493867 @default.
• W2133011641 hasConceptScore W2133011641C59822182 @default.
• W2133011641 hasConceptScore W2133011641C86803240 @default.
• W2133011641 hasConceptScore W2133011641C95444343 @default.
• W2133011641 hasIssue "2" @default.
• W2133011641 hasLocation W21330116411 @default.

• next