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- W2133067785 abstract "To describe demographics, employment, insurance, medication adherence and healthcare utilization of patients with severe asthma. This was an asthma cohort study (age 12-75 years) requiring three initial claims within three months for omalizumab, high-intensity corticosteroids (HICS; ≥1000 μg/day fluticasone equivalent or oral prednisone), or high-dose inhaled corticosteroid (HDICS; ≥500 to <1000 μg/day fluticasone equivalent) from 2002-2011.Adherence was assessed using the annualized Medication Possession Ratio (MPR: % of year taking medication). Of 70,343 patients, 1,046 initiated omalizumab, 24,319 initiated HICS, and 44,978 initiated HDICS. More severe cohorts (omalizumab, HICS, and HDICS, respectively) had higher pre-index mean values for medical expenditures ($14,071; $12,030 and $7570), utilization (27 outpatient and 10 specialty care visits; 19 outpatient and 2 specialty; 15 outpatient and 2 specialty), asthma-related prescription drugs (11.74; 7.8; 5.17) and chronic comorbidities (2.68; 2.67 and 2.19). In the year prior to omalizumab treatment: 72% of patients were taking HICS (MPR 30%), 64% oral corticosteroids (MPR 13%), 33% HDICS (MPR 40%), 63% leukotrienes (MPR 54%) and 69% short-acting beta agonists (29%); these patients were more likely to be salaried, full-time employees with commercial PPO/POS insurance. Categorizing severe asthma patients by treatment cohorts provides more granular focus augmenting GINA categorization. Increased severity was associated with higher baseline healthcare expenditures and utilization. Prior to omalizumab treatment, most patients were taking high doses of corticosteroids. The high utilization and polypharmacy burden may reflect failures in standard of care and its treatment options prior to titrating to the next step of therapy." @default.
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- W2133067785 date "2014-02-01" @default.
- W2133067785 modified "2023-09-27" @default.
- W2133067785 title "Characterizing The Severe Asthma Population In The United States: Claims-Based Analysis Of Three Treatment Cohorts In The Year Prior To Treatment Escalation" @default.
- W2133067785 doi "https://doi.org/10.1016/j.jaci.2013.12.173" @default.
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