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• W2133108719 endingPage "1919" @default.
• W2133108719 startingPage "1909" @default.
• W2133108719 abstract "Sin Nombre virus (SNV) causes hantavirus pulmonary syndrome (HPS), with a high rate of mortality in humans who are infected by the transmission of virus from the natural rodent host. In humans, cytotoxic T lymphocytes (CTL) specific for SNV appear to play an important role in the pathogenicity of HPS. There is a correlation between the frequencies of SNV-specific CTLs and the severity of HPS disease. In order to create a mouse model to study the role of SNV-specific T cells in vivo , T cell responses to SNV nucleocapsid (N) protein in B6.PL Thy1 a /Cy mice (H-2 b ) immunized with plasmid DNA or recombinant vaccinia virus expressing SNV N protein were examined. Four peptides, NC94–101, NC175–189, NC217–231 and NC331–345, were recognized by CD8 + T cells in CTL and ELISPOT assays in SNV N-immunized mice. Interestingly, two of these epitopes are located in the central region of the SNV N protein, where several human CD8 + T-cell epitopes have been defined in Puumala virus and SNV. CTL lines specific for these four epitopes were cross-reactive to corresponding Puumala virus peptides, but only one of them was cross-reactive to Hantaan virus peptides. These results will enable the analysis of the roles of CTL in immunopathology of HPS in experimental mouse models of HPS." @default.
• W2133108719 created "2016-06-24" @default.
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• W2133108719 date "2004-07-01" @default.
• W2133108719 modified "2023-10-03" @default.
• W2133108719 title "Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein" @default.
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• W2133108719 doi "https://doi.org/10.1099/vir.0.79945-0" @default.
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