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• W2133114315 abstract "d-Penicillamine (d-Pen) is a thiol drug used in the treatment of Wilson’s disease, rheumatoid arthritis, metal intoxication and cystinuria. We have recently described a new capillary electrophoresis (CE) method to measure physiological thiols, in which separation of total plasma homocysteine, cysteine, cysteinylglycine, glutathione is achieved using the organic base N-methyl-d-glucamine in the run buffer. In this paper, we present an improvement of our method that allows a baseline separation of total plasma d-Pen from the physiological thiols. Moreover, reduced, free and protein-bound forms of drug are measured by varying the order of disulfide reduction with tributylphosphine and proteins precipitation with 5-sulphosalicylic acid (SSA). After derivatization with 5-iodoacetamidofluorescein (5-IAF), samples are separated and measured by capillary electrophoresis with laser-induced fluorescence in an uncoated fused-silica capillary (57cm×75 μm i.d.) using a phosphate/borate run buffer pH 11.4. In these conditions, the migration time of d-Pen is about 7 min and the time required for each analysis is roughly 10 min. The proposed method has been utilized to measure the various forms of the drug in a d-Pen administered Wilson’s disease patient." @default.
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• W2133114315 date "2004-04-01" @default.
• W2133114315 modified "2023-09-27" @default.
• W2133114315 title "Plasma d-penicillamine redox state evaluation by capillary electrophoresis with laser-induced fluorescence" @default.
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• W2133114315 doi "https://doi.org/10.1016/j.jchromb.2004.01.002" @default.
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