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• W2133115365 abstract "Thermodynamic analysis of ligand-target binding has been a useful tool for dissecting the nature of the binding mechanism and, therefore, potentially can provide valuable information regarding the utility of targeted formulations. Based on a consistent coupling of antibody–antigen binding and gel–liquid crystal transition energetics observed for antibody–phosphatidylethanolamine (Ab–PE) conjugates, we hypothesized that the thermodynamic parameters and the affinity for antigen of the Ab–PE conjugates could be effectively predicted once the corresponding information for the unconjugated antibody is determined. This hypothesis has now been tested in nine different antibody-targeted echogenic liposome (ELIP) preparations, where antibody is conjugated to dipalmitoylphosphatidylethanolamine (DPPE) head groups through a thioether linkage. Predictions were satisfactory (affinity not significantly different from the population of values found) in five cases (55.6%), but the affinity of the unconjugated antibody was not significantly different from the population of values found in six cases (66.7%), indicating that the affinities of the conjugated antibody tended not to deviate appreciably from those of the free antibody. While knowledge of the affinities of free antibodies may be sufficient to judge their suitability as targeting agents, thermodynamic analysis may still provide valuable information regarding their usefulness for specific applications." @default.
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• W2133115365 date "2014-03-06" @default.
• W2133115365 modified "2023-10-02" @default.
• W2133115365 title "Use of thermodynamic coupling between antibody–antigen binding and phospholipid acyl chain phase transition energetics to predict immunoliposome targeting affinity" @default.
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• W2133115365 doi "https://doi.org/10.3109/08982104.2014.891230" @default.
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