Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133127894> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2133127894 endingPage "7" @default.
- W2133127894 startingPage "3374" @default.
- W2133127894 abstract "Monoclonal antibody HT462 recognizes a human T-cell leukemia virus type I (HTLV-I)-associated Mr 52,000 glycoprotein (HA-gp52), which is found on the surface of HTLV-infected cells. Whether HA-gp52 is encoded by the virus or by the infected cells has not yet been established. Using monoclonal HT462 in a competitive binding assay, natural human antibodies specific for HA-gp52 were detected in 97% of the patients from the United States, the Caribbean, and Japan with adult T-cell leukemia but not in healthy donors not exposed to HTLV-I. In contrast, antibodies to HA-gp52 occur in healthy virus-exposed donors, but at a lower prevalence than that observed in patients. Among Japanese from HTLV-I-endemic areas and exposed to the virus as indicated by the presence of antibodies to disrupted HTLV-I, 93% of adult T-cell leukemia patients were also seropositive for HA-gp52 compared to only 16% of healthy individuals. Differing sensitivities in the methods of assaying antibodies to HTLV and HA-gp52 were not responsible for these observations as shown by the lack of correlation of HTLV-I antibody titer with the presence of antibody to HA-gp52. Among adult T-cell leukemia patients, antibody titers to HTLV-I and HA-gp52 also varied independently. These results indicate that HA-gp52 in humans is antigenic and correlated with disease. Detection of antibody to this protein in asymptomatic individuals may be indicative of a predisease condition." @default.
- W2133127894 created "2016-06-24" @default.
- W2133127894 creator A5067964875 @default.
- W2133127894 creator A5088474933 @default.
- W2133127894 date "1985-07-01" @default.
- W2133127894 modified "2023-09-23" @default.
- W2133127894 title "Antigenicity of human T-cell leukemia virus-associated gp52: greater response in leukemia patients compared to healthy donors exposed to the virus." @default.
- W2133127894 cites W147221144 @default.
- W2133127894 cites W1560344387 @default.
- W2133127894 cites W1596403146 @default.
- W2133127894 cites W1966288685 @default.
- W2133127894 cites W1966681398 @default.
- W2133127894 cites W1968873679 @default.
- W2133127894 cites W1977461031 @default.
- W2133127894 cites W1979637191 @default.
- W2133127894 cites W1981906666 @default.
- W2133127894 cites W1991670386 @default.
- W2133127894 cites W1995684414 @default.
- W2133127894 cites W1998355439 @default.
- W2133127894 cites W2002321879 @default.
- W2133127894 cites W2003085418 @default.
- W2133127894 cites W2005988457 @default.
- W2133127894 cites W2008582644 @default.
- W2133127894 cites W2052050039 @default.
- W2133127894 cites W2074996399 @default.
- W2133127894 cites W2086143621 @default.
- W2133127894 cites W2094507249 @default.
- W2133127894 cites W2136021515 @default.
- W2133127894 cites W2408719768 @default.
- W2133127894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2988770" @default.
- W2133127894 hasPublicationYear "1985" @default.
- W2133127894 type Work @default.
- W2133127894 sameAs 2133127894 @default.
- W2133127894 citedByCount "1" @default.
- W2133127894 crossrefType "journal-article" @default.
- W2133127894 hasAuthorship W2133127894A5067964875 @default.
- W2133127894 hasAuthorship W2133127894A5088474933 @default.
- W2133127894 hasConcept C147483822 @default.
- W2133127894 hasConcept C159047783 @default.
- W2133127894 hasConcept C159654299 @default.
- W2133127894 hasConcept C203014093 @default.
- W2133127894 hasConcept C2522874641 @default.
- W2133127894 hasConcept C2776913467 @default.
- W2133127894 hasConcept C2778461978 @default.
- W2133127894 hasConcept C2779026604 @default.
- W2133127894 hasConcept C32611913 @default.
- W2133127894 hasConcept C542903549 @default.
- W2133127894 hasConcept C71924100 @default.
- W2133127894 hasConcept C86803240 @default.
- W2133127894 hasConceptScore W2133127894C147483822 @default.
- W2133127894 hasConceptScore W2133127894C159047783 @default.
- W2133127894 hasConceptScore W2133127894C159654299 @default.
- W2133127894 hasConceptScore W2133127894C203014093 @default.
- W2133127894 hasConceptScore W2133127894C2522874641 @default.
- W2133127894 hasConceptScore W2133127894C2776913467 @default.
- W2133127894 hasConceptScore W2133127894C2778461978 @default.
- W2133127894 hasConceptScore W2133127894C2779026604 @default.
- W2133127894 hasConceptScore W2133127894C32611913 @default.
- W2133127894 hasConceptScore W2133127894C542903549 @default.
- W2133127894 hasConceptScore W2133127894C71924100 @default.
- W2133127894 hasConceptScore W2133127894C86803240 @default.
- W2133127894 hasIssue "7" @default.
- W2133127894 hasLocation W21331278941 @default.
- W2133127894 hasOpenAccess W2133127894 @default.
- W2133127894 hasPrimaryLocation W21331278941 @default.
- W2133127894 hasRelatedWork W1968866496 @default.
- W2133127894 hasRelatedWork W2033826705 @default.
- W2133127894 hasRelatedWork W2082523390 @default.
- W2133127894 hasRelatedWork W2098556738 @default.
- W2133127894 hasRelatedWork W2149850078 @default.
- W2133127894 hasRelatedWork W2291652652 @default.
- W2133127894 hasRelatedWork W2355835824 @default.
- W2133127894 hasRelatedWork W2399786269 @default.
- W2133127894 hasRelatedWork W2567673387 @default.
- W2133127894 hasRelatedWork W3046632723 @default.
- W2133127894 hasVolume "45" @default.
- W2133127894 isParatext "false" @default.
- W2133127894 isRetracted "false" @default.
- W2133127894 magId "2133127894" @default.
- W2133127894 workType "article" @default.