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- W2133130607 abstract "Caenorhabditis elegans has been proven to be a useful model organism for investigating molecular and cellular aspects of numerous human diseases. More recently, investigators have explored the use of this organism as a tool for drug discovery. Although earlier drug screens were labor-intensive and low in throughput, recent advances in high-throughput liquid workflows, imaging platforms and data analysis software have made C. elegans a viable option for automated high-throughput drug screens. This review will outline the evolution of C. elegans-based drug screening, discuss the inherent challenges of using C. elegans, and highlight recent technological advances that have paved the way for future drug screens." @default.
- W2133130607 created "2016-06-24" @default.
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- W2133130607 date "2014-04-01" @default.
- W2133130607 modified "2023-09-27" @default.
- W2133130607 title "C. elegans in high-throughput drug discovery" @default.
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- W2133130607 doi "https://doi.org/10.1016/j.addr.2013.12.001" @default.
- W2133130607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4019719" @default.
- W2133130607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24333896" @default.
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