FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133130908> ?p ?o ?g. }

• W2133130908 endingPage "305" @default.
• W2133130908 startingPage "294" @default.
• W2133130908 abstract "The covarion hypothesis of molecular evolution proposes that selective pressures on an amino acid or nucleotide site change through time, thus causing changes of evolutionary rate along the edges of a phylogenetic tree. Several kinds of Markov models for the covarion process have been proposed. One model, proposed by Huelsenbeck (2002), has 2 substitution rate classes: the substitution process at a site can switch between a single variable rate, drawn from a discrete gamma distribution, and a zero invariable rate. A second model, suggested by Galtier (2001), assumes rate switches among an arbitrary number of rate classes but switching to and from the invariable rate class is not allowed. The latter model allows for some sites that do not participate in the rate-switching process. Here we propose a general covarion model that combines features of both models, allowing evolutionary rates not only to switch between variable and invariable classes but also to switch among different rates when they are in a variable state. We have implemented all 3 covarion models in a maximum likelihood framework for amino acid sequences and tested them on 23 protein data sets. We found significant likelihood increases for all data sets for the 3 models, compared with a model that does not allow site-specific rate switches along the tree. Furthermore, we found that the general model fit the data better than the simpler covarion models in the majority of the cases, highlighting the complexity in modeling the covarion process. The general covarion model can be used for comparing tree topologies, molecular dating studies, and the investigation of protein adaptation." @default.
• W2133130908 created "2016-06-24" @default.
• W2133130908 creator A5021576212 @default.
• W2133130908 creator A5036388754 @default.
• W2133130908 creator A5053095410 @default.
• W2133130908 creator A5081686489 @default.
• W2133130908 date "2006-10-20" @default.
• W2133130908 modified "2023-10-12" @default.
• W2133130908 title "Testing for Covarion-like Evolution in Protein Sequences" @default.
• W2133130908 cites W1634598038 @default.
• W2133130908 cites W1963957860 @default.
• W2133130908 cites W1969345623 @default.
• W2133130908 cites W1969914058 @default.
• W2133130908 cites W1975041634 @default.
• W2133130908 cites W1981737570 @default.
• W2133130908 cites W1985151213 @default.
• W2133130908 cites W1988024444 @default.
• W2133130908 cites W1996019265 @default.
• W2133130908 cites W2008196159 @default.
• W2133130908 cites W2019907599 @default.
• W2133130908 cites W2021630728 @default.
• W2133130908 cites W2027881855 @default.
• W2133130908 cites W2029423438 @default.
• W2133130908 cites W2031818329 @default.
• W2133130908 cites W2036272181 @default.
• W2133130908 cites W2046076301 @default.
• W2133130908 cites W2048788203 @default.
• W2133130908 cites W2049203248 @default.
• W2133130908 cites W2053082690 @default.
• W2133130908 cites W2062598923 @default.
• W2133130908 cites W2095247458 @default.
• W2133130908 cites W2102424972 @default.
• W2133130908 cites W2103546861 @default.
• W2133130908 cites W2104988583 @default.
• W2133130908 cites W2105487208 @default.
• W2133130908 cites W2106329053 @default.
• W2133130908 cites W2115415644 @default.
• W2133130908 cites W2119900532 @default.
• W2133130908 cites W2124785691 @default.
• W2133130908 cites W2124790653 @default.
• W2133130908 cites W2131985618 @default.
• W2133130908 cites W2134304337 @default.
• W2133130908 cites W2139677507 @default.
• W2133130908 cites W2141333644 @default.
• W2133130908 cites W2145694091 @default.
• W2133130908 cites W2150948320 @default.
• W2133130908 cites W2152529266 @default.
• W2133130908 cites W2154266095 @default.
• W2133130908 cites W2155310681 @default.
• W2133130908 cites W2161444534 @default.
• W2133130908 cites W2163123197 @default.
• W2133130908 cites W2165985875 @default.
• W2133130908 cites W2169226135 @default.
• W2133130908 cites W2171319187 @default.
• W2133130908 doi "https://doi.org/10.1093/molbev/msl155" @default.
• W2133130908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17056642" @default.
• W2133130908 hasPublicationYear "2006" @default.
• W2133130908 type Work @default.
• W2133130908 sameAs 2133130908 @default.
• W2133130908 citedByCount "75" @default.
• W2133130908 countsByYear W21331309082012 @default.
• W2133130908 countsByYear W21331309082013 @default.
• W2133130908 countsByYear W21331309082014 @default.
• W2133130908 countsByYear W21331309082015 @default.
• W2133130908 countsByYear W21331309082016 @default.
• W2133130908 countsByYear W21331309082017 @default.
• W2133130908 countsByYear W21331309082018 @default.
• W2133130908 countsByYear W21331309082019 @default.
• W2133130908 countsByYear W21331309082020 @default.
• W2133130908 countsByYear W21331309082021 @default.
• W2133130908 countsByYear W21331309082022 @default.
• W2133130908 crossrefType "journal-article" @default.
• W2133130908 hasAuthorship W2133130908A5021576212 @default.
• W2133130908 hasAuthorship W2133130908A5036388754 @default.
• W2133130908 hasAuthorship W2133130908A5053095410 @default.
• W2133130908 hasAuthorship W2133130908A5081686489 @default.
• W2133130908 hasBestOaLocation W21331309081 @default.
• W2133130908 hasConcept C104317684 @default.
• W2133130908 hasConcept C105795698 @default.
• W2133130908 hasConcept C111919701 @default.
• W2133130908 hasConcept C113174947 @default.
• W2133130908 hasConcept C114614502 @default.
• W2133130908 hasConcept C134306372 @default.
• W2133130908 hasConcept C163836022 @default.
• W2133130908 hasConcept C182365436 @default.
• W2133130908 hasConcept C186060115 @default.
• W2133130908 hasConcept C193252679 @default.
• W2133130908 hasConcept C199360897 @default.
• W2133130908 hasConcept C2778220771 @default.
• W2133130908 hasConcept C2992240565 @default.
• W2133130908 hasConcept C33923547 @default.
• W2133130908 hasConcept C41008148 @default.
• W2133130908 hasConcept C54355233 @default.
• W2133130908 hasConcept C86803240 @default.
• W2133130908 hasConcept C98045186 @default.
• W2133130908 hasConcept C98763669 @default.
• W2133130908 hasConceptScore W2133130908C104317684 @default.
• W2133130908 hasConceptScore W2133130908C105795698 @default.

• next