FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133132485> ?p ?o ?g. }

• W2133132485 abstract "The prevalence of children diagnosed with deep vein thrombosis or pulmonary embolism has been increasing in the last decade. The most common thrombosis risk factor in neonates, infants and children is the placement of a central venous catheter (CVC). To date, it is unknown if the practice of anticoagulation prophylaxis with low molecular weight heparin (LMWH) decreases CVC-related thrombosis in children.The primary objective of this review was to determine the effect of LMWH prophylaxis on reducing the incidence of CVC-related thrombosis in children.Secondary objectives were to determine the effect of LMWH on occlusion of CVCs, number of days of CVC patency, episodes of catheter-related sepsis, side effects of LMWH (allergic reactions, major and minor bleeding complications, abnormal coagulation profile, osteoporosis) and mortality during therapy.The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (last searched June 2013), CENTRAL (2013, Issue 5) and clinical trial databases. The authors searched MEDLINE and EMBASE (July 2013). Bibliographies of identified articles were searched. There were no language restrictions.Randomised and quasi-randomised trials comparing LMWH prophylaxis to standard care given to prevent CVC-related thrombotic events in children were included. We selected studies conducted in children aged 0 to 18 years.Two review authors independently identified eligible studies, which were assessed for study quality including bias, and extracted unadjusted data where available. In the data analysis step, all outcomes were analysed as binary or dichotomous outcomes. The effects of interventions were summarised with risk ratios (RR) and their respective 95% confidence intervals (CI).One of 17 studies retrieved for full-text assessment for eligibility was included in the final analysis. This study included a total of 186 participants and investigated the effect of LMWH to prevent CVC-related thrombosis compared to standard care. The risk of bias of the study was assessed to be low, except for the unclear risk of selection bias (allocation concealment not reported) and detection bias since it was an open-label study. Nonetheless, outcome adjudication was blinded. However, overall the quality of the evidence was low due to the fact that the study was underpowered. The CIs for the risk of CVC-related thrombosis (symptomatic and asymptomatic events) were compatible with benefits of either LMWH (reviparin) or the control (RR for symptomatic thrombosis 1.03, 95% CI 0.21 to 4.93; RR for asymptomatic thrombosis 1.17, 95% CI 0.45 to 3.08). Similarly, only one patient in the standard care group suffered a major bleeding event, while minor bleeding was found in 53.3% of patients in the reviparin arm and in 44.7% of patients in the standard care arm (major bleeding RR 0.34, 95% CI 0.01 to 8.26; minor bleeding RR 1.20, 95% CI 0.91 to 1.58). Lastly, there were two deaths within the study and neither were the result of a venous thrombotic event (VTE), occurring in the standard care arm. No additional adverse effects were reported. Other pre-specified outcomes for this review were not reported.A single study reported imprecise effects for the risk of CVC-related thrombosis in children on a CVC anticoagulant prophylaxis regimen. The quality of the evidence was low due to the fact that the included study was clearly underpowered, hampering any conclusions in regards to the efficacy of LMWH prophylaxis to prevent CVC-related thrombi in children. Further prospective randomised studies are highly encouraged." @default.
• W2133132485 created "2016-06-24" @default.
• W2133132485 creator A5016775524 @default.
• W2133132485 creator A5035738307 @default.
• W2133132485 creator A5066197445 @default.
• W2133132485 date "2014-03-10" @default.
• W2133132485 modified "2023-09-24" @default.
• W2133132485 title "Low molecular weight heparin for prevention of central venous catheterization-related thrombosis in children" @default.
• W2133132485 cites W1527739777 @default.
• W2133132485 cites W1554040650 @default.
• W2133132485 cites W1770147359 @default.
• W2133132485 cites W1973816714 @default.
• W2133132485 cites W2002877608 @default.
• W2133132485 cites W2016544425 @default.
• W2133132485 cites W2034128870 @default.
• W2133132485 cites W2051659244 @default.
• W2133132485 cites W2055074660 @default.
• W2133132485 cites W2055736858 @default.
• W2133132485 cites W2059667538 @default.
• W2133132485 cites W2070752931 @default.
• W2133132485 cites W2072246423 @default.
• W2133132485 cites W2074105102 @default.
• W2133132485 cites W2074161987 @default.
• W2133132485 cites W2077189133 @default.
• W2133132485 cites W2085292470 @default.
• W2133132485 cites W2085899166 @default.
• W2133132485 cites W2087210684 @default.
• W2133132485 cites W2103419160 @default.
• W2133132485 cites W2106459062 @default.
• W2133132485 cites W2106763942 @default.
• W2133132485 cites W2108043885 @default.
• W2133132485 cites W2112145906 @default.
• W2133132485 cites W2117564285 @default.
• W2133132485 cites W2124015273 @default.
• W2133132485 cites W2130646692 @default.
• W2133132485 cites W2134236426 @default.
• W2133132485 cites W2139716972 @default.
• W2133132485 cites W2142688154 @default.
• W2133132485 cites W2152672882 @default.
• W2133132485 cites W2171677057 @default.
• W2133132485 cites W2171955666 @default.
• W2133132485 cites W2312343429 @default.
• W2133132485 cites W2320648654 @default.
• W2133132485 cites W2400065648 @default.
• W2133132485 cites W62537 @default.
• W2133132485 doi "https://doi.org/10.1002/14651858.cd005982.pub2" @default.
• W2133132485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7390480" @default.
• W2133132485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32557627" @default.
• W2133132485 hasPublicationYear "2014" @default.
• W2133132485 type Work @default.
• W2133132485 sameAs 2133132485 @default.
• W2133132485 citedByCount "12" @default.
• W2133132485 countsByYear W21331324852015 @default.
• W2133132485 countsByYear W21331324852016 @default.
• W2133132485 countsByYear W21331324852017 @default.
• W2133132485 countsByYear W21331324852018 @default.
• W2133132485 countsByYear W21331324852020 @default.
• W2133132485 countsByYear W21331324852021 @default.
• W2133132485 crossrefType "journal-article" @default.
• W2133132485 hasAuthorship W2133132485A5016775524 @default.
• W2133132485 hasAuthorship W2133132485A5035738307 @default.
• W2133132485 hasAuthorship W2133132485A5066197445 @default.
• W2133132485 hasBestOaLocation W21331324851 @default.
• W2133132485 hasConcept C120665830 @default.
• W2133132485 hasConcept C121332964 @default.
• W2133132485 hasConcept C126322002 @default.
• W2133132485 hasConcept C141071460 @default.
• W2133132485 hasConcept C187212893 @default.
• W2133132485 hasConcept C2776265017 @default.
• W2133132485 hasConcept C2776877702 @default.
• W2133132485 hasConcept C2776884760 @default.
• W2133132485 hasConcept C2778446481 @default.
• W2133132485 hasConcept C2778959117 @default.
• W2133132485 hasConcept C2780011451 @default.
• W2133132485 hasConcept C2780868729 @default.
• W2133132485 hasConcept C2781267111 @default.
• W2133132485 hasConcept C2991741193 @default.
• W2133132485 hasConcept C61511704 @default.
• W2133132485 hasConcept C71924100 @default.
• W2133132485 hasConcept C95190672 @default.
• W2133132485 hasConceptScore W2133132485C120665830 @default.
• W2133132485 hasConceptScore W2133132485C121332964 @default.
• W2133132485 hasConceptScore W2133132485C126322002 @default.
• W2133132485 hasConceptScore W2133132485C141071460 @default.
• W2133132485 hasConceptScore W2133132485C187212893 @default.
• W2133132485 hasConceptScore W2133132485C2776265017 @default.
• W2133132485 hasConceptScore W2133132485C2776877702 @default.
• W2133132485 hasConceptScore W2133132485C2776884760 @default.
• W2133132485 hasConceptScore W2133132485C2778446481 @default.
• W2133132485 hasConceptScore W2133132485C2778959117 @default.
• W2133132485 hasConceptScore W2133132485C2780011451 @default.
• W2133132485 hasConceptScore W2133132485C2780868729 @default.
• W2133132485 hasConceptScore W2133132485C2781267111 @default.
• W2133132485 hasConceptScore W2133132485C2991741193 @default.
• W2133132485 hasConceptScore W2133132485C61511704 @default.
• W2133132485 hasConceptScore W2133132485C71924100 @default.
• W2133132485 hasConceptScore W2133132485C95190672 @default.
• W2133132485 hasLocation W21331324851 @default.
• W2133132485 hasLocation W21331324852 @default.
• W2133132485 hasOpenAccess W2133132485 @default.

• next