Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133141633> ?p ?o ?g. }
- W2133141633 endingPage "4238" @default.
- W2133141633 startingPage "4218" @default.
- W2133141633 abstract "Histone deacetylase (HDAC) inhibitors are a group of anticancer drugs which cause growth arrest and apoptosis of several tumor cells. HDAC inhibitors have been also found to increase the anticancer efficacy of several treatment modalities i.e. chemotherapy or radiotherapy. Here, we review the literature on combinations of HDAC inhibitors both with ionizing radiation and with other drugs, highlighting DNA-damaging compounds. The results of numerous studies with several types of cancer cells discussed in this review demonstrate that HDAC inhibitors enhance the effect of DNA damaging agents, such as inhibitors of topoisomerases, inhibitors of DNA synthesis, DNA-intercalators and agents covalently modifying DNA (i.e. doxorubicin, etoposid, 5-fluorouracil, cisplatin, melphalan, temozolomide and ellipticine) or of irradiation. Hence, the use of HDAC inhibitors combined with these antitumor drugs or ionizing radiation is a promising tool which may make treatment of patients suffering from many types of cancer more efficient. Several molecular mechanisms are responsible for the observed higher sensitivity of tumor cells towards therapeutic agents elicited by HDAC inhibitors. These mechanisms are discussed also in this review." @default.
- W2133141633 created "2016-06-24" @default.
- W2133141633 creator A5009212415 @default.
- W2133141633 creator A5009700689 @default.
- W2133141633 creator A5013532796 @default.
- W2133141633 creator A5019351423 @default.
- W2133141633 creator A5055879543 @default.
- W2133141633 creator A5071937644 @default.
- W2133141633 creator A5077879348 @default.
- W2133141633 date "2012-09-01" @default.
- W2133141633 modified "2023-09-23" @default.
- W2133141633 title "The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment" @default.
- W2133141633 cites W1006224826 @default.
- W2133141633 cites W125325141 @default.
- W2133141633 cites W1509538618 @default.
- W2133141633 cites W1511815964 @default.
- W2133141633 cites W1542404140 @default.
- W2133141633 cites W154704142 @default.
- W2133141633 cites W1567485746 @default.
- W2133141633 cites W1607892649 @default.
- W2133141633 cites W1658998365 @default.
- W2133141633 cites W1678800844 @default.
- W2133141633 cites W1899314386 @default.
- W2133141633 cites W1935102817 @default.
- W2133141633 cites W1946962189 @default.
- W2133141633 cites W1966731347 @default.
- W2133141633 cites W1966977158 @default.
- W2133141633 cites W1967018540 @default.
- W2133141633 cites W1968972540 @default.
- W2133141633 cites W1969106931 @default.
- W2133141633 cites W1969161297 @default.
- W2133141633 cites W1969173613 @default.
- W2133141633 cites W1969249015 @default.
- W2133141633 cites W1969283097 @default.
- W2133141633 cites W1969323007 @default.
- W2133141633 cites W1969893714 @default.
- W2133141633 cites W1970417286 @default.
- W2133141633 cites W1971631987 @default.
- W2133141633 cites W1972104782 @default.
- W2133141633 cites W1972846893 @default.
- W2133141633 cites W1973962086 @default.
- W2133141633 cites W1974090542 @default.
- W2133141633 cites W1974277276 @default.
- W2133141633 cites W1976856958 @default.
- W2133141633 cites W1981015662 @default.
- W2133141633 cites W1981353115 @default.
- W2133141633 cites W1984254481 @default.
- W2133141633 cites W1986866765 @default.
- W2133141633 cites W1987172374 @default.
- W2133141633 cites W1988284872 @default.
- W2133141633 cites W1989696433 @default.
- W2133141633 cites W1990452435 @default.
- W2133141633 cites W1990801507 @default.
- W2133141633 cites W1991000956 @default.
- W2133141633 cites W1991615588 @default.
- W2133141633 cites W1992125449 @default.
- W2133141633 cites W1992586037 @default.
- W2133141633 cites W1993208712 @default.
- W2133141633 cites W1993238109 @default.
- W2133141633 cites W1993655008 @default.
- W2133141633 cites W1996103159 @default.
- W2133141633 cites W1996387142 @default.
- W2133141633 cites W1996809397 @default.
- W2133141633 cites W1997154923 @default.
- W2133141633 cites W1997392910 @default.
- W2133141633 cites W1997961866 @default.
- W2133141633 cites W1998635761 @default.
- W2133141633 cites W1999122953 @default.
- W2133141633 cites W2000056961 @default.
- W2133141633 cites W2000431894 @default.
- W2133141633 cites W2001465534 @default.
- W2133141633 cites W2003837981 @default.
- W2133141633 cites W2004980848 @default.
- W2133141633 cites W2008054969 @default.
- W2133141633 cites W2008446710 @default.
- W2133141633 cites W2011625842 @default.
- W2133141633 cites W2011712519 @default.
- W2133141633 cites W2011767163 @default.
- W2133141633 cites W2012298748 @default.
- W2133141633 cites W2012778393 @default.
- W2133141633 cites W2013313605 @default.
- W2133141633 cites W2014330039 @default.
- W2133141633 cites W2016254453 @default.
- W2133141633 cites W2016521087 @default.
- W2133141633 cites W2017187312 @default.
- W2133141633 cites W2018272903 @default.
- W2133141633 cites W2018976177 @default.
- W2133141633 cites W2020236755 @default.
- W2133141633 cites W2021172314 @default.
- W2133141633 cites W2021638634 @default.
- W2133141633 cites W2022774864 @default.
- W2133141633 cites W2023237279 @default.
- W2133141633 cites W2023520741 @default.
- W2133141633 cites W2023983787 @default.
- W2133141633 cites W2025273529 @default.
- W2133141633 cites W2026549010 @default.
- W2133141633 cites W2026694991 @default.
- W2133141633 cites W2027029112 @default.