FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133156739> ?p ?o ?g. }

• W2133156739 endingPage "204" @default.
• W2133156739 startingPage "193" @default.
• W2133156739 abstract "The field of infectious diseases is in urgent need of new approaches to antimicrobial therapy. Radio-immunotherapy (RIT) has evolved into successful therapy for certain malignancies. Published preclinical and clinical investigations have demonstrated that radiolabeled microorganism-specific antibodies localize to tissue sites of bacterial and fungal infection. The potential of RIT as an antimicrobial treatment strategy has not been developed clinically, which could reflect lack of awareness of the difficult problems in clinical infectious diseases by the nuclear medicine community and of RIT by the infectious diseases physicians. We have recently demonstrated the feasibility of using RIT for treating murine cryptococcosis using a monoclonal antibody to Crypto-coccus neoformans capsular glucuronoxylomannan labeled with Bismuth-213 or Rhenium-188. Subsequently, we showed the applicability of RIT to bacterial (Streptococcus pneumonia) and viral (HIV-1) infections. Treatment did not cause acute hematologic toxicity in treated animals. The mechanisms of RIT of infection include killing of microbial cells by ''direct hit'' and ''cross-fire'' effects, promotion of apoptosis-like death, cooperation with macrophages and modulation of the inflammatory response. RIT for infection is theoretically useful for any microbe susceptible to radiation, including bacteria, fungi, viruses and parasites. The promise of this technique is based on the fact that the technology is largely in place and that the only requirements are availability of microbe-specific monoclonal antibodies and suitable radionuclides. In fact, one could anticipate that targeting microbes will be easier than targeting neoplastic cells when the enormous antigenic differences between host and microbes are taken into consideration. However, considerable basic work remains to be done to ascertain the optimal conditions for the efficacy of RIT for infection." @default.
• W2133156739 created "2016-06-24" @default.
• W2133156739 creator A5034610205 @default.
• W2133156739 creator A5077902719 @default.
• W2133156739 date "2006-09-01" @default.
• W2133156739 modified "2023-09-28" @default.
• W2133156739 title "Treatment of infection with radiolabeled antibodies." @default.
• W2133156739 cites W1505033636 @default.
• W2133156739 cites W1826412460 @default.
• W2133156739 cites W1828953816 @default.
• W2133156739 cites W1846243321 @default.
• W2133156739 cites W1868687951 @default.
• W2133156739 cites W1965606695 @default.
• W2133156739 cites W1970405229 @default.
• W2133156739 cites W1970536180 @default.
• W2133156739 cites W1976520588 @default.
• W2133156739 cites W1977294492 @default.
• W2133156739 cites W1978247129 @default.
• W2133156739 cites W1987175539 @default.
• W2133156739 cites W1992274022 @default.
• W2133156739 cites W1995200174 @default.
• W2133156739 cites W2014654561 @default.
• W2133156739 cites W2019391534 @default.
• W2133156739 cites W2023259463 @default.
• W2133156739 cites W2025008283 @default.
• W2133156739 cites W2029394645 @default.
• W2133156739 cites W2034924732 @default.
• W2133156739 cites W2037282660 @default.
• W2133156739 cites W2038985192 @default.
• W2133156739 cites W2039962854 @default.
• W2133156739 cites W2044374875 @default.
• W2133156739 cites W2047551799 @default.
• W2133156739 cites W2048254406 @default.
• W2133156739 cites W2048450977 @default.
• W2133156739 cites W2066451326 @default.
• W2133156739 cites W2066501151 @default.
• W2133156739 cites W2067007577 @default.
• W2133156739 cites W2067925914 @default.
• W2133156739 cites W2070459956 @default.
• W2133156739 cites W2071059905 @default.
• W2133156739 cites W2073946113 @default.
• W2133156739 cites W2084355977 @default.
• W2133156739 cites W2095820961 @default.
• W2133156739 cites W2102108185 @default.
• W2133156739 cites W2102540369 @default.
• W2133156739 cites W2104225375 @default.
• W2133156739 cites W2106052007 @default.
• W2133156739 cites W2108782926 @default.
• W2133156739 cites W2123953807 @default.
• W2133156739 cites W2126076750 @default.
• W2133156739 cites W2127901889 @default.
• W2133156739 cites W2132723673 @default.
• W2133156739 cites W2140894005 @default.
• W2133156739 cites W2156113285 @default.
• W2133156739 cites W2169147691 @default.
• W2133156739 cites W2255993428 @default.
• W2133156739 cites W2338393014 @default.
• W2133156739 cites W2440288526 @default.
• W2133156739 cites W2615655254 @default.
• W2133156739 cites W2073201027 @default.
• W2133156739 cites W2343642095 @default.
• W2133156739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16868533" @default.
• W2133156739 hasPublicationYear "2006" @default.
• W2133156739 type Work @default.
• W2133156739 sameAs 2133156739 @default.
• W2133156739 citedByCount "4" @default.
• W2133156739 countsByYear W21331567392016 @default.
• W2133156739 crossrefType "journal-article" @default.
• W2133156739 hasAuthorship W2133156739A5034610205 @default.
• W2133156739 hasAuthorship W2133156739A5077902719 @default.
• W2133156739 hasConcept C159047783 @default.
• W2133156739 hasConcept C159654299 @default.
• W2133156739 hasConcept C203014093 @default.
• W2133156739 hasConcept C2776146153 @default.
• W2133156739 hasConcept C2777701055 @default.
• W2133156739 hasConcept C2777893358 @default.
• W2133156739 hasConcept C2779413141 @default.
• W2133156739 hasConcept C4937899 @default.
• W2133156739 hasConcept C542903549 @default.
• W2133156739 hasConcept C71924100 @default.
• W2133156739 hasConcept C86803240 @default.
• W2133156739 hasConcept C8891405 @default.
• W2133156739 hasConcept C89423630 @default.
• W2133156739 hasConceptScore W2133156739C159047783 @default.
• W2133156739 hasConceptScore W2133156739C159654299 @default.
• W2133156739 hasConceptScore W2133156739C203014093 @default.
• W2133156739 hasConceptScore W2133156739C2776146153 @default.
• W2133156739 hasConceptScore W2133156739C2777701055 @default.
• W2133156739 hasConceptScore W2133156739C2777893358 @default.
• W2133156739 hasConceptScore W2133156739C2779413141 @default.
• W2133156739 hasConceptScore W2133156739C4937899 @default.
• W2133156739 hasConceptScore W2133156739C542903549 @default.
• W2133156739 hasConceptScore W2133156739C71924100 @default.
• W2133156739 hasConceptScore W2133156739C86803240 @default.
• W2133156739 hasConceptScore W2133156739C8891405 @default.
• W2133156739 hasConceptScore W2133156739C89423630 @default.
• W2133156739 hasIssue "3" @default.
• W2133156739 hasLocation W21331567391 @default.

• next