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• W2133166054 abstract "Recent progress in the RNA therapeutics has increased demand for the synthesis of large quantities of oligoribonucleotides. The assembly of RNA oligomers relies mainly on solid-phase approaches. These allow rapid product purification and the ability to drive a target reaction to completion through the use of excess reagents. Despite the known advantages of solid-phase synthesis, some issues in the process remain to be addressed, such as low and limited scale, reagent accessibility, and the use of a very large excess of reagents. Herein, we report a highly efficient and practical method of liquid-phase synthesis of RNA oligomers by using alkyl-chain-soluble support. We demonstrate the utility of the liquid-phase method through 21-mer RNA synthesis on a gram scale." @default.
• W2133166054 created "2016-06-24" @default.
• W2133166054 creator A5026667398 @default.
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• W2133166054 date "2013-05-09" @default.
• W2133166054 modified "2023-09-26" @default.
• W2133166054 title "Liquid-Phase RNA Synthesis by Using Alkyl-Chain-Soluble Support" @default.
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• W2133166054 doi "https://doi.org/10.1002/chem.201300655" @default.
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