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• W2133183716 abstract "The acute phase response (APR) is a set of metabolic and physiological reactions occurring in the host in response to tissue infection or injury and is a crucial component of the larger innate immune response. The APR is best characterized by dramatic changes in the concentration of a group of plasma proteins known as acute phase proteins (APPs) which are synthesized in the liver and function in a wide range of immunity-related activities. Utilizing a new high-density in situ oligonucleotide microarray, we have evaluated the APR in channel catfish liver following infection with Edwardsiella ictaluri, a bacterial pathogen that causes enteric septicemia of catfish. Our catfish microarray design (28K) builds upon a previous 19K channel catfish array by adding recently sequenced immune transcripts from channel catfish along with 7159 unique sequences from closely related blue catfish. The analysis of microarray results using a traditional 2-fold change in gene expression cutoff and a 10% false-discovery rate revealed a well-developed APR in catfish, with particularly high upregulation (>50-fold) of genes involved in iron homeostasis (i.e. intelectin, hemopexin, haptoglobin, ferritin, and transferrin). Other classical APP genes upregulated greater than 2-fold included coagulation factors, proteinase inhibitors, transport proteins, and complement components. Upregulation of the majority of the complement cascade was observed including the membrane attack complex components and complement inhibitors. A number of pathogen recognition receptors (PRRs) and chemokines were also differentially expressed in the liver following infection. Independent testing of a selection of differentially expressed genes with real-time RT-PCR confirmed microarray results." @default.
• W2133183716 created "2016-06-24" @default.
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• W2133183716 date "2007-01-01" @default.
• W2133183716 modified "2023-10-09" @default.
• W2133183716 title "Expression analysis of the acute phase response in channel catfish (Ictalurus punctatus) after infection with a Gram-negative bacterium" @default.
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• W2133183716 cites W1596965334 @default.
• W2133183716 cites W1607444523 @default.
• W2133183716 cites W192753270 @default.
• W2133183716 cites W1967137199 @default.
• W2133183716 cites W1967497464 @default.
• W2133183716 cites W1968223166 @default.
• W2133183716 cites W1968876085 @default.
• W2133183716 cites W1972721300 @default.
• W2133183716 cites W1972994912 @default.
• W2133183716 cites W1980042430 @default.
• W2133183716 cites W1990564189 @default.
• W2133183716 cites W1993343933 @default.
• W2133183716 cites W1996539617 @default.
• W2133183716 cites W2001873744 @default.
• W2133183716 cites W2006002758 @default.
• W2133183716 cites W2007810446 @default.
• W2133183716 cites W2013354167 @default.
• W2133183716 cites W2015457320 @default.
• W2133183716 cites W2018146526 @default.
• W2133183716 cites W2021129827 @default.
• W2133183716 cites W2021487333 @default.
• W2133183716 cites W2022452100 @default.
• W2133183716 cites W2022972180 @default.
• W2133183716 cites W2025063713 @default.
• W2133183716 cites W2026858016 @default.
• W2133183716 cites W2026894281 @default.
• W2133183716 cites W2032429886 @default.
• W2133183716 cites W2032625731 @default.
• W2133183716 cites W2032689229 @default.
• W2133183716 cites W2035323516 @default.
• W2133183716 cites W2037354367 @default.
• W2133183716 cites W2043465498 @default.
• W2133183716 cites W2051781207 @default.
• W2133183716 cites W2055058467 @default.
• W2133183716 cites W2059284948 @default.
• W2133183716 cites W2060998289 @default.
• W2133183716 cites W2061321571 @default.
• W2133183716 cites W2062548620 @default.
• W2133183716 cites W2064736210 @default.
• W2133183716 cites W2064850668 @default.
• W2133183716 cites W2066497770 @default.
• W2133183716 cites W2069402589 @default.
• W2133183716 cites W2072649421 @default.
• W2133183716 cites W2078664576 @default.
• W2133183716 cites W2082897117 @default.
• W2133183716 cites W2086023076 @default.
• W2133183716 cites W2086857328 @default.
• W2133183716 cites W2090673358 @default.
• W2133183716 cites W2095090055 @default.
• W2133183716 cites W2099434149 @default.
• W2133183716 cites W2101045680 @default.
• W2133183716 cites W2104991132 @default.
• W2133183716 cites W2108244474 @default.
• W2133183716 cites W2117212863 @default.
• W2133183716 cites W2120865735 @default.
• W2133183716 cites W2128909276 @default.
• W2133183716 cites W2129844981 @default.
• W2133183716 cites W2130501069 @default.
• W2133183716 cites W2132308784 @default.
• W2133183716 cites W2148769103 @default.
• W2133183716 cites W2154764208 @default.
• W2133183716 cites W2156604637 @default.
• W2133183716 cites W2157129863 @default.
• W2133183716 cites W2165926265 @default.
• W2133183716 cites W2170989872 @default.
• W2133183716 cites W2317184793 @default.
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• W2133183716 doi "https://doi.org/10.1016/j.dci.2007.03.003" @default.
• W2133183716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17449095" @default.
• W2133183716 hasPublicationYear "2007" @default.
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