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• W2133191750 endingPage "e56833" @default.
• W2133191750 startingPage "e56833" @default.
• W2133191750 abstract "Background Protein-protein interactions are critical to elucidating the role played by individual proteins in important biological pathways. Of particular interest are hub proteins that can interact with large numbers of partners and often play essential roles in cellular control. Depending on the number of binding sites, protein hubs can be classified at a structural level as singlish-interface hubs (SIH) with one or two binding sites, or multiple-interface hubs (MIH) with three or more binding sites. In terms of kinetics, hub proteins can be classified as date hubs (i.e., interact with different partners at different times or locations) or party hubs (i.e., simultaneously interact with multiple partners). Methodology Our approach works in 3 phases: Phase I classifies if a protein is likely to bind with another protein. Phase II determines if a protein-binding (PB) protein is a hub. Phase III classifies PB proteins as singlish-interface versus multiple-interface hubs and date versus party hubs. At each stage, we use sequence-based predictors trained using several standard machine learning techniques. Conclusions Our method is able to predict whether a protein is a protein-binding protein with an accuracy of 94% and a correlation coefficient of 0.87; identify hubs from non-hubs with 100% accuracy for 30% of the data; distinguish date hubs/party hubs with 69% accuracy and area under ROC curve of 0.68; and SIH/MIH with 89% accuracy and area under ROC curve of 0.84. Because our method is based on sequence information alone, it can be used even in settings where reliable protein-protein interaction data or structures of protein-protein complexes are unavailable to obtain useful insights into the functional and evolutionary characteristics of proteins and their interactions. Availability We provide a web server for our three-phase approach: http://hybsvm.gdcb.iastate.edu." @default.
• W2133191750 created "2016-06-24" @default.
• W2133191750 creator A5004737962 @default.
• W2133191750 creator A5022049098 @default.
• W2133191750 creator A5045214155 @default.
• W2133191750 date "2013-02-19" @default.
• W2133191750 modified "2023-09-30" @default.
• W2133191750 title "Predicting the Binding Patterns of Hub Proteins: A Study Using Yeast Protein Interaction Networks" @default.
• W2133191750 cites W1512098439 @default.
• W2133191750 cites W1533936090 @default.
• W2133191750 cites W1551622300 @default.
• W2133191750 cites W1554576613 @default.
• W2133191750 cites W1973626596 @default.
• W2133191750 cites W1976937534 @default.
• W2133191750 cites W1980800453 @default.
• W2133191750 cites W1984476827 @default.
• W2133191750 cites W1987560617 @default.
• W2133191750 cites W1998203484 @default.
• W2133191750 cites W2002159909 @default.
• W2133191750 cites W2006062026 @default.
• W2133191750 cites W2006837755 @default.
• W2133191750 cites W2008138629 @default.
• W2133191750 cites W2012852001 @default.
• W2133191750 cites W2014761306 @default.
• W2133191750 cites W2015802360 @default.
• W2133191750 cites W2022196194 @default.
• W2133191750 cites W2037036397 @default.
• W2133191750 cites W2037796399 @default.
• W2133191750 cites W2039465881 @default.
• W2133191750 cites W2047544230 @default.
• W2133191750 cites W2049275721 @default.
• W2133191750 cites W2055043387 @default.
• W2133191750 cites W2063961010 @default.
• W2133191750 cites W2065304353 @default.
• W2133191750 cites W2067305633 @default.
• W2133191750 cites W2067410215 @default.
• W2133191750 cites W2071753136 @default.
• W2133191750 cites W2076789164 @default.
• W2133191750 cites W2084619201 @default.
• W2133191750 cites W2087574732 @default.
• W2133191750 cites W2094392347 @default.
• W2133191750 cites W2096253801 @default.
• W2133191750 cites W2096358531 @default.
• W2133191750 cites W2096864392 @default.
• W2133191750 cites W2101330776 @default.
• W2133191750 cites W2103485392 @default.
• W2133191750 cites W2104437738 @default.
• W2133191750 cites W2107040871 @default.
• W2133191750 cites W2107424557 @default.
• W2133191750 cites W2107432340 @default.
• W2133191750 cites W2108608653 @default.
• W2133191750 cites W2109248504 @default.
• W2133191750 cites W2109300715 @default.
• W2133191750 cites W2111286354 @default.
• W2133191750 cites W2113654464 @default.
• W2133191750 cites W2114875557 @default.
• W2133191750 cites W2119782490 @default.
• W2133191750 cites W2125013516 @default.
• W2133191750 cites W2125725297 @default.
• W2133191750 cites W2126717546 @default.
• W2133191750 cites W2128653811 @default.
• W2133191750 cites W2129776684 @default.
• W2133191750 cites W2130790725 @default.
• W2133191750 cites W2132582966 @default.
• W2133191750 cites W2135893370 @default.
• W2133191750 cites W2137175516 @default.
• W2133191750 cites W2140883620 @default.
• W2133191750 cites W2141885858 @default.
• W2133191750 cites W2150066952 @default.
• W2133191750 cites W2152285853 @default.
• W2133191750 cites W2158714788 @default.
• W2133191750 cites W2166558964 @default.
• W2133191750 cites W2167785155 @default.
• W2133191750 cites W2167867998 @default.
• W2133191750 cites W2167869241 @default.
• W2133191750 cites W2168264491 @default.
• W2133191750 cites W2312695517 @default.
• W2133191750 cites W2915108429 @default.
• W2133191750 cites W4210531204 @default.
• W2133191750 cites W4210623056 @default.
• W2133191750 cites W4236956086 @default.
• W2133191750 cites W4255855797 @default.
• W2133191750 doi "https://doi.org/10.1371/journal.pone.0056833" @default.
• W2133191750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3576370" @default.
• W2133191750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23431393" @default.
• W2133191750 hasPublicationYear "2013" @default.
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