Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133194106> ?p ?o ?g. }
- W2133194106 endingPage "162" @default.
- W2133194106 startingPage "153" @default.
- W2133194106 abstract "Meclofenamic acid (MFA) sustained-release microspheres were prepared by the solvent evaporation method using cellulose propionate (CP) polymer and acetone as the polymer solvent. Polyethylene glycol (PEG) was used as a channelling agent to improve the release properties of MFA at 1:2:1 drug to polymer to PEG ratio. The microspheres prepared at three different speeds (600, 800 and 1000 rpm) were characterized with regard to their surface morphology, average drug content, particle size distribution and release profiles in phosphate buffer, pH 8.0 at 37°C. The microspheres were stored under accelerated conditions for 3 months and the effect of storage on the different characteristics was studied. Spherical particles with essentially smooth surface and few residual drug crystals on the surface were formed. Smaller particles were formed at higher agitation speeds. The release rate of MFA from these microspheres was not affected by the molecular weight of CP polymer. PEG 2000 was found to have a more enhancing effect on the rate of the release than PEG 4000. The physical properties of the microspheres and their release characteristics were not altered by storing the product at 40°C/80% relative humidity (R.H.) for 3 months." @default.
- W2133194106 created "2016-06-24" @default.
- W2133194106 creator A5056192697 @default.
- W2133194106 creator A5063188130 @default.
- W2133194106 creator A5076639774 @default.
- W2133194106 date "1998-01-01" @default.
- W2133194106 modified "2023-10-18" @default.
- W2133194106 title "Development and<i>in-vitro</i>evaluation of sustained-release meclofenamic acid microspheres" @default.
- W2133194106 cites W1988468764 @default.
- W2133194106 cites W2001395739 @default.
- W2133194106 cites W2009692443 @default.
- W2133194106 cites W2012362831 @default.
- W2133194106 cites W2062859183 @default.
- W2133194106 cites W2067434394 @default.
- W2133194106 cites W2091542835 @default.
- W2133194106 cites W2108405555 @default.
- W2133194106 cites W2143798559 @default.
- W2133194106 doi "https://doi.org/10.3109/02652049809006845" @default.
- W2133194106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9532521" @default.
- W2133194106 hasPublicationYear "1998" @default.
- W2133194106 type Work @default.
- W2133194106 sameAs 2133194106 @default.
- W2133194106 citedByCount "10" @default.
- W2133194106 countsByYear W21331941062014 @default.
- W2133194106 countsByYear W21331941062020 @default.
- W2133194106 crossrefType "journal-article" @default.
- W2133194106 hasAuthorship W2133194106A5056192697 @default.
- W2133194106 hasAuthorship W2133194106A5063188130 @default.
- W2133194106 hasAuthorship W2133194106A5076639774 @default.
- W2133194106 hasConcept C10138342 @default.
- W2133194106 hasConcept C121332964 @default.
- W2133194106 hasConcept C127413603 @default.
- W2133194106 hasConcept C13245373 @default.
- W2133194106 hasConcept C13965031 @default.
- W2133194106 hasConcept C158960510 @default.
- W2133194106 hasConcept C159985019 @default.
- W2133194106 hasConcept C162324750 @default.
- W2133194106 hasConcept C171250308 @default.
- W2133194106 hasConcept C178790620 @default.
- W2133194106 hasConcept C185592680 @default.
- W2133194106 hasConcept C187530423 @default.
- W2133194106 hasConcept C192562407 @default.
- W2133194106 hasConcept C2776035855 @default.
- W2133194106 hasConcept C2776964284 @default.
- W2133194106 hasConcept C2777521759 @default.
- W2133194106 hasConcept C2779820397 @default.
- W2133194106 hasConcept C2780471494 @default.
- W2133194106 hasConcept C2781213060 @default.
- W2133194106 hasConcept C42360764 @default.
- W2133194106 hasConcept C43617362 @default.
- W2133194106 hasConcept C521977710 @default.
- W2133194106 hasConcept C54400483 @default.
- W2133194106 hasConcept C77281830 @default.
- W2133194106 hasConcept C97355855 @default.
- W2133194106 hasConceptScore W2133194106C10138342 @default.
- W2133194106 hasConceptScore W2133194106C121332964 @default.
- W2133194106 hasConceptScore W2133194106C127413603 @default.
- W2133194106 hasConceptScore W2133194106C13245373 @default.
- W2133194106 hasConceptScore W2133194106C13965031 @default.
- W2133194106 hasConceptScore W2133194106C158960510 @default.
- W2133194106 hasConceptScore W2133194106C159985019 @default.
- W2133194106 hasConceptScore W2133194106C162324750 @default.
- W2133194106 hasConceptScore W2133194106C171250308 @default.
- W2133194106 hasConceptScore W2133194106C178790620 @default.
- W2133194106 hasConceptScore W2133194106C185592680 @default.
- W2133194106 hasConceptScore W2133194106C187530423 @default.
- W2133194106 hasConceptScore W2133194106C192562407 @default.
- W2133194106 hasConceptScore W2133194106C2776035855 @default.
- W2133194106 hasConceptScore W2133194106C2776964284 @default.
- W2133194106 hasConceptScore W2133194106C2777521759 @default.
- W2133194106 hasConceptScore W2133194106C2779820397 @default.
- W2133194106 hasConceptScore W2133194106C2780471494 @default.
- W2133194106 hasConceptScore W2133194106C2781213060 @default.
- W2133194106 hasConceptScore W2133194106C42360764 @default.
- W2133194106 hasConceptScore W2133194106C43617362 @default.
- W2133194106 hasConceptScore W2133194106C521977710 @default.
- W2133194106 hasConceptScore W2133194106C54400483 @default.
- W2133194106 hasConceptScore W2133194106C77281830 @default.
- W2133194106 hasConceptScore W2133194106C97355855 @default.
- W2133194106 hasIssue "2" @default.
- W2133194106 hasLocation W21331941061 @default.
- W2133194106 hasLocation W21331941062 @default.
- W2133194106 hasOpenAccess W2133194106 @default.
- W2133194106 hasPrimaryLocation W21331941061 @default.
- W2133194106 hasRelatedWork W1974471610 @default.
- W2133194106 hasRelatedWork W1988468764 @default.
- W2133194106 hasRelatedWork W2036219699 @default.
- W2133194106 hasRelatedWork W2065800254 @default.
- W2133194106 hasRelatedWork W2089853857 @default.
- W2133194106 hasRelatedWork W2127005302 @default.
- W2133194106 hasRelatedWork W2366773372 @default.
- W2133194106 hasRelatedWork W2389635566 @default.
- W2133194106 hasRelatedWork W4292583891 @default.
- W2133194106 hasRelatedWork W2187932669 @default.
- W2133194106 hasVolume "15" @default.
- W2133194106 isParatext "false" @default.
- W2133194106 isRetracted "false" @default.
- W2133194106 magId "2133194106" @default.