Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133199635> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2133199635 endingPage "53" @default.
- W2133199635 startingPage "648" @default.
- W2133199635 abstract "Slices of rat temporo-parietal cortex were prelabeled with gamma-[3H]aminobutyric acid ([3H]GABA), in the presence of the glial GABA uptake inhibitor beta-alanine. The slices were then superfused with a medium containing the GABA transaminase inhibitor aminooxyacetic acid and stimulated electrically (5 min, 2 msec, 36 mA at 5 or 10 Hz), in the presence of the neuronal GABA reuptake inhibitor SK&F 89976A [N-(4,4-diphenyl-3-butenyl)-nipecotic acid] and of beta-alanine. Representative experiments showed that the tritium released could be accounted for almost entirely by authentic [3H]GABA. The electrically evoked overflow of [3H]GABA was tetrodotoxin sensitive and largely calcium-dependent. Exogenous GABA, added to the superfusion medium at 3 to 30 microM, reduced in a concentration-dependent manner the electrically evoked (5 Hz) release of [3H]GABA. The GABAB receptor agonist (-)-baclofen, but not the GABAA receptor agonist muscimol, mimicked GABA and produced a concentration-inhibition curve almost superimposable to that of the natural transmitter. The effects of GABA and of (-)-baclofen were much more pronounced at 5 than at 10 Hz. The GABA-induced inhibition of [3H]GABA release was sensitive to the novel GABAB receptor antagonist beta-(p-chlorophenyl)-3-amino propyl phosphonic acid which, by itself, increased the [3H]GABA overflow. The inhibitory effect of GABA was not counteracted by the GABAA receptor antagonists bicuculline or SR 95531 [2-(3'-carbethoxy-2'-propenyl)-3-amino-6-paramethoxy-phenyl-pyr idazinium bromide]. The results are compatible with the presence in the rat cerebral cortex of autoreceptors mediating inhibition of GABA release and belonging to the GABAB type. These autoreceptors may be activated tonically under physiological conditions." @default.
- W2133199635 created "2016-06-24" @default.
- W2133199635 creator A5015779278 @default.
- W2133199635 creator A5037065292 @default.
- W2133199635 creator A5048232498 @default.
- W2133199635 date "1989-08-01" @default.
- W2133199635 modified "2023-09-23" @default.
- W2133199635 title "Release of gamma-[3H]aminobutyric acid (GABA) from electrically stimulated rat cortical slices and its modulation by GABAB autoreceptors." @default.
- W2133199635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2547942" @default.
- W2133199635 hasPublicationYear "1989" @default.
- W2133199635 type Work @default.
- W2133199635 sameAs 2133199635 @default.
- W2133199635 citedByCount "7" @default.
- W2133199635 crossrefType "journal-article" @default.
- W2133199635 hasAuthorship W2133199635A5015779278 @default.
- W2133199635 hasAuthorship W2133199635A5037065292 @default.
- W2133199635 hasAuthorship W2133199635A5048232498 @default.
- W2133199635 hasConcept C101027131 @default.
- W2133199635 hasConcept C126322002 @default.
- W2133199635 hasConcept C134018914 @default.
- W2133199635 hasConcept C168258287 @default.
- W2133199635 hasConcept C170493617 @default.
- W2133199635 hasConcept C181199279 @default.
- W2133199635 hasConcept C185592680 @default.
- W2133199635 hasConcept C2776055257 @default.
- W2133199635 hasConcept C2776219046 @default.
- W2133199635 hasConcept C2776627618 @default.
- W2133199635 hasConcept C2777771985 @default.
- W2133199635 hasConcept C2778938600 @default.
- W2133199635 hasConcept C2779188335 @default.
- W2133199635 hasConcept C2779324764 @default.
- W2133199635 hasConcept C2779414652 @default.
- W2133199635 hasConcept C2780763569 @default.
- W2133199635 hasConcept C2781201050 @default.
- W2133199635 hasConcept C55493867 @default.
- W2133199635 hasConcept C71924100 @default.
- W2133199635 hasConcept C79636183 @default.
- W2133199635 hasConcept C8439214 @default.
- W2133199635 hasConcept C86803240 @default.
- W2133199635 hasConceptScore W2133199635C101027131 @default.
- W2133199635 hasConceptScore W2133199635C126322002 @default.
- W2133199635 hasConceptScore W2133199635C134018914 @default.
- W2133199635 hasConceptScore W2133199635C168258287 @default.
- W2133199635 hasConceptScore W2133199635C170493617 @default.
- W2133199635 hasConceptScore W2133199635C181199279 @default.
- W2133199635 hasConceptScore W2133199635C185592680 @default.
- W2133199635 hasConceptScore W2133199635C2776055257 @default.
- W2133199635 hasConceptScore W2133199635C2776219046 @default.
- W2133199635 hasConceptScore W2133199635C2776627618 @default.
- W2133199635 hasConceptScore W2133199635C2777771985 @default.
- W2133199635 hasConceptScore W2133199635C2778938600 @default.
- W2133199635 hasConceptScore W2133199635C2779188335 @default.
- W2133199635 hasConceptScore W2133199635C2779324764 @default.
- W2133199635 hasConceptScore W2133199635C2779414652 @default.
- W2133199635 hasConceptScore W2133199635C2780763569 @default.
- W2133199635 hasConceptScore W2133199635C2781201050 @default.
- W2133199635 hasConceptScore W2133199635C55493867 @default.
- W2133199635 hasConceptScore W2133199635C71924100 @default.
- W2133199635 hasConceptScore W2133199635C79636183 @default.
- W2133199635 hasConceptScore W2133199635C8439214 @default.
- W2133199635 hasConceptScore W2133199635C86803240 @default.
- W2133199635 hasIssue "2" @default.
- W2133199635 hasLocation W21331996351 @default.
- W2133199635 hasOpenAccess W2133199635 @default.
- W2133199635 hasPrimaryLocation W21331996351 @default.
- W2133199635 hasRelatedWork W1985893094 @default.
- W2133199635 hasRelatedWork W2020466006 @default.
- W2133199635 hasRelatedWork W2021586534 @default.
- W2133199635 hasRelatedWork W2035711960 @default.
- W2133199635 hasRelatedWork W2050166784 @default.
- W2133199635 hasRelatedWork W2086262995 @default.
- W2133199635 hasRelatedWork W2095158829 @default.
- W2133199635 hasRelatedWork W2133199635 @default.
- W2133199635 hasRelatedWork W2414086578 @default.
- W2133199635 hasRelatedWork W2436601398 @default.
- W2133199635 hasVolume "250" @default.
- W2133199635 isParatext "false" @default.
- W2133199635 isRetracted "false" @default.
- W2133199635 magId "2133199635" @default.
- W2133199635 workType "article" @default.