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• W2133202198 abstract "<b>Background/Aim:</b> This study was performed to evaluate the prevalence of celiac disease (CD) in Shiraz, southern Iran. <b> Materials and Methods:</b> Serum samples were collected from 1440 persons (age range = 20-83 years, mean age = 45.4 years) in 2004 and screened for endomysial and tissue transglutaminase antibodies. A questionnaire was completed for all subjects in relation to gastrointestinal (GI) symptoms and cases with positive serology were requested to undergo small-bowel biopsy. <b> Results</b> : Seven cases (0.5%) were positive for IgA anti-tissue transglutaminase (anti-tTG), and only two (0.14%) were positive for IgA anti-endomysial antibody (anti-EMA), both of whom had highly positive anti-tTg levels (40.4 and 48.0 IU/l). The major clinical symptoms of CD, such as recurrent abdominal pain and change in bowel habits were present in all patients with positive anti-tTG assays. Only five subjects with positive serology agreed to undergo upper GI endoscopy and duodenal biopsy. Three of these cases were reported with Marsh I histologic findings, while in the two cases with positive serologic anti-EMA, more advanced forms of CD were present. <b> Conclusion:</b> The prevalence of CD in apparently healthy adults was lower than the reported series from northern parts of the country; therefore, we suggest a more long-term follow-up study in high-risk groups, especially in the apparently healthy subjects in our region." @default.
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• W2133202198 date "2008-01-01" @default.
• W2133202198 modified "2023-10-16" @default.
• W2133202198 title "Prevalence of celiac disease in Shiraz, southern Iran" @default.
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• W2133202198 doi "https://doi.org/10.4103/1319-3767.41732" @default.
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