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• W2133205211 startingPage "829" @default.
• W2133205211 abstract "A clinic-based case-control study was conducted to determine the association between vitamin supplement use and risk of basal cell carcinoma (BCC) of the skin. The subjects were 131 patients with histopathologically confirmed primary BCC and 200 cancer-free controls with non-premalignant skin disorders. Use of any vitamins (mainly multivitamins and vitamins A, C, and E) was associated with reduced risk of BCC. After controlling for age, sex, cigarette smoking, number of lifetime severe sunburns, and skin actinic elastosis, regular vitamin supplementation was associated with a significantly reduced risk of BCC (odds ratio (OR) = 0.3; 95% confidence interval (CI) = 0.2−0.6). The ORs decreased as the regularity (p < 0.001) and daily doses of supplement used increased, especially for vitamins A (p < 0.005) and E (p < 0.005). Vitamin supplementation was not associated with alterations in cellular DNA repair. These results, however, cannot be considered conclusive because of the relatively low participation rates ( for cases and for controls) due to the requirement of blood donation and more rigorous studies are needed to clarify the effect of supplemental vitamins, particularly of vitamins A and E, on the risk of BCC of the skin." @default.
• W2133205211 created "2016-06-24" @default.
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• W2133205211 date "1994-08-01" @default.
• W2133205211 modified "2023-10-18" @default.
• W2133205211 title "Vitamin supplementation and reduced risk of basal cell carcinoma" @default.
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• W2133205211 doi "https://doi.org/10.1016/0895-4356(94)90185-6" @default.
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• W2133205211 hasPublicationYear "1994" @default.
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