FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133233410> ?p ?o ?g. }

• W2133233410 endingPage "183" @default.
• W2133233410 startingPage "174" @default.
• W2133233410 abstract "Wilms tumor (WT) is a genetically heterogeneous childhood kidney tumor. Several genetic alterations have been identified in WT patients, including inactivating mutations in WT1 and loss of heterozygosity or loss of imprinting at 11p15, which results in biallelic expression of IGF2. However, the mechanisms by which one or a combination of genetic alterations results in tumorigenesis has remained challenging to determine, given the lack of a mouse model of WT. Here, we engineered mice to sustain mosaic, somatic ablation of Wt1 and constitutional Igf2 upregulation, mimicking a subset of human tumors. Mice with this combination of genetic alterations developed tumors at an early age. Mechanistically, Wt1 ablation blocked mesenchyme differentiation, and increased Igf2 expression upregulated ERK1/2 phosphorylation. Importantly, a subset of human tumors similarly displayed upregulation of ERK1/2 phosphorylation, which suggests ERK signaling might contribute to WT development. Thus, we have generated a biologically relevant mouse model of WT and defined one combination of driver alterations for WT. This mouse model will provide a powerful tool to study the biology of WT initiation and progression and to investigate therapeutic strategies for cancers with IGF pathway dysregulation." @default.
• W2133233410 created "2016-06-24" @default.
• W2133233410 creator A5001199496 @default.
• W2133233410 creator A5010620653 @default.
• W2133233410 creator A5014283643 @default.
• W2133233410 creator A5027863723 @default.
• W2133233410 creator A5050445982 @default.
• W2133233410 creator A5051741610 @default.
• W2133233410 creator A5051784653 @default.
• W2133233410 creator A5060302560 @default.
• W2133233410 creator A5065388010 @default.
• W2133233410 creator A5080788580 @default.
• W2133233410 date "2011-01-04" @default.
• W2133233410 modified "2023-10-16" @default.
• W2133233410 title "Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation" @default.
• W2133233410 cites W1923107379 @default.
• W2133233410 cites W1967588153 @default.
• W2133233410 cites W1971689970 @default.
• W2133233410 cites W1975680353 @default.
• W2133233410 cites W1980020302 @default.
• W2133233410 cites W1981496258 @default.
• W2133233410 cites W1983228128 @default.
• W2133233410 cites W1986934770 @default.
• W2133233410 cites W1989853936 @default.
• W2133233410 cites W1995574948 @default.
• W2133233410 cites W1999089403 @default.
• W2133233410 cites W1999466077 @default.
• W2133233410 cites W2008585163 @default.
• W2133233410 cites W2011399707 @default.
• W2133233410 cites W2014404936 @default.
• W2133233410 cites W2035951460 @default.
• W2133233410 cites W2036733820 @default.
• W2133233410 cites W2039309643 @default.
• W2133233410 cites W2040157600 @default.
• W2133233410 cites W2042742511 @default.
• W2133233410 cites W2048838478 @default.
• W2133233410 cites W2058275656 @default.
• W2133233410 cites W2065570057 @default.
• W2133233410 cites W2068992396 @default.
• W2133233410 cites W2074647644 @default.
• W2133233410 cites W2075993202 @default.
• W2133233410 cites W2077668550 @default.
• W2133233410 cites W2083216339 @default.
• W2133233410 cites W2083356835 @default.
• W2133233410 cites W2084585178 @default.
• W2133233410 cites W2089171551 @default.
• W2133233410 cites W2094207651 @default.
• W2133233410 cites W2095579742 @default.
• W2133233410 cites W2105878939 @default.
• W2133233410 cites W2107277218 @default.
• W2133233410 cites W2114245705 @default.
• W2133233410 cites W2118567330 @default.
• W2133233410 cites W2120328308 @default.
• W2133233410 cites W2126983941 @default.
• W2133233410 cites W2143371665 @default.
• W2133233410 cites W2143416290 @default.
• W2133233410 cites W2150926065 @default.
• W2133233410 cites W2152509610 @default.
• W2133233410 cites W2158190901 @default.
• W2133233410 cites W2167589429 @default.
• W2133233410 cites W2168740151 @default.
• W2133233410 cites W2186049400 @default.
• W2133233410 doi "https://doi.org/10.1172/jci43772" @default.
• W2133233410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3007149" @default.
• W2133233410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21123950" @default.
• W2133233410 hasPublicationYear "2011" @default.
• W2133233410 type Work @default.
• W2133233410 sameAs 2133233410 @default.
• W2133233410 citedByCount "105" @default.
• W2133233410 countsByYear W21332334102012 @default.
• W2133233410 countsByYear W21332334102013 @default.
• W2133233410 countsByYear W21332334102014 @default.
• W2133233410 countsByYear W21332334102015 @default.
• W2133233410 countsByYear W21332334102016 @default.
• W2133233410 countsByYear W21332334102017 @default.
• W2133233410 countsByYear W21332334102018 @default.
• W2133233410 countsByYear W21332334102019 @default.
• W2133233410 countsByYear W21332334102020 @default.
• W2133233410 countsByYear W21332334102021 @default.
• W2133233410 countsByYear W21332334102022 @default.
• W2133233410 countsByYear W21332334102023 @default.
• W2133233410 crossrefType "journal-article" @default.
• W2133233410 hasAuthorship W2133233410A5001199496 @default.
• W2133233410 hasAuthorship W2133233410A5010620653 @default.
• W2133233410 hasAuthorship W2133233410A5014283643 @default.
• W2133233410 hasAuthorship W2133233410A5027863723 @default.
• W2133233410 hasAuthorship W2133233410A5050445982 @default.
• W2133233410 hasAuthorship W2133233410A5051741610 @default.
• W2133233410 hasAuthorship W2133233410A5051784653 @default.
• W2133233410 hasAuthorship W2133233410A5060302560 @default.
• W2133233410 hasAuthorship W2133233410A5065388010 @default.
• W2133233410 hasAuthorship W2133233410A5080788580 @default.
• W2133233410 hasBestOaLocation W21332334101 @default.
• W2133233410 hasConcept C104317684 @default.
• W2133233410 hasConcept C11960822 @default.
• W2133233410 hasConcept C121608353 @default.
• W2133233410 hasConcept C127561419 @default.
• W2133233410 hasConcept C134305767 @default.

• next