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• W2133236396 abstract "Abstract Objectives : Fractones are extracellular matrix structures that form a niche for neural stem cells and their immediate progeny in the subventricular zone of the lateral ventricle (SVZa), the primary neurogenic zone in the adult brain. We have previously shown that heparan sulphates (HS) associated with fractones bind fibroblast growth factor‐2 (FGF‐2), a powerful mitotic growth factor in the SVZa. Here, our objective was to determine whether the binding of FGF‐2 to fractone‐HS is implicated in the mechanism leading to cell proliferation in the SVZa. Materials and methods : Heparitinase‐1 was intracerebroventricularly injected with FGF‐2 to N‐desulfate HS proteoglycans and determine whether the loss of HS and of FGF‐2 binding to fractones modifies FGF‐2 effect on cell proliferation. We also examined in vivo the binding of Alexa‐Fluor‐FGF‐2 in relationship with the location of HS immunoreactivity in the SVZa. Results : Heparatinase‐1 drastically reduced the stimulatory effect of FGF‐2 on cell proliferation in the SVZa. Alexa‐Fluor‐FGF‐2 binding was strictly co‐localized with HS immunoreactivity in fractones and adjacent vascular basement membranes in the SVZa. Conclusions : Our results demonstrate that FGF‐2 requires HS to stimulate cell proliferation in the SVZa and suggest that HS associated with fractones and vascular basement membranes are responsible for activating FGF‐2. Therefore, fractones and vascular basement membranes may function as a HS niche to drive cell proliferation in the adult neurogenic zone." @default.
• W2133236396 created "2016-06-24" @default.
• W2133236396 creator A5011617108 @default.
• W2133236396 creator A5014088858 @default.
• W2133236396 creator A5053527406 @default.
• W2133236396 creator A5057074151 @default.
• W2133236396 date "2013-03-19" @default.
• W2133236396 modified "2023-10-14" @default.
• W2133236396 title "Fractone‐heparan sulphates mediate FGF‐2 stimulation of cell proliferation in the adult subventricular zone" @default.
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• W2133236396 doi "https://doi.org/10.1111/cpr.12023" @default.
• W2133236396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6495915" @default.
• W2133236396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23510468" @default.
• W2133236396 hasPublicationYear "2013" @default.
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