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• W2133240010 abstract "There is a great need for a rapid diagnostic test to guide vaccine choice during outbreaks of meningococcal meningitis in resource-poor countries. During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex® latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. Results from 484 samples showed a sensitivity of 88% (95% CI 85–91%) and a specificity of 93% (95% CI 90–95%). Pastorex® could be a good alternative to current methods, as it can be performed in a local laboratory with rapid results and is highly specific. Sensitivity can be improved with prior microscopy where feasible. A study specifically to evaluate the Pastorex® test under epidemic conditions, using laboratories with limited resources, is recommended." @default.
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• W2133240010 date "2006-10-01" @default.
• W2133240010 modified "2023-10-14" @default.
• W2133240010 title "High sensitivity and specificity of the Pastorex® latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger" @default.
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• W2133240010 doi "https://doi.org/10.1016/j.trstmh.2006.03.002" @default.
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