FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133241939> ?p ?o ?g. }

• W2133241939 endingPage "193" @default.
• W2133241939 startingPage "189" @default.
• W2133241939 abstract "Background: Even after successful radical treatment of lung cancer, patients in stages I and II of the TNM system very frequently suffer recurrence, which end lethally. Detection of subclinical residual disease after surgery is thus one of the most important emerging diagnostic methods. Minimal residual disease (MRD) is defined as the presence of isolated tumor cells or circulating cells in a patient after curative primary tumor removal and at the same time, no clinical signs of cancer. Conventional methods cannot detect minimal residual disease and hence there is a need for detection using new molecular biological methods. Methods: We searched the PubMed database for original and review articles on minimal residual disease in lung cancer. Search words were lung cancer, minimal residual disease and detection of minimal residual disease. The publications we found were compared with the results of our own studies on the detection of minimal residual disease in lung cancer and the personal experiences are described. Examination of blood samples from 98 healthy volunteers and bone marrow from 12 patients with non inflammatory and non tumour illness, were used to determine cut-off values for specific markers in the compartments. Subsequently, expression of selected markers in tumor tissue was analysed in a pilot sample of 50 patients with lung cancer and the presence of MRD was measured as expression of values of the tested markers correlated with clinico-pathological characteristics. Conclusions: Recent studies on other malignancies apart from lung cancer have shown the importance of MRD detection in the determination of disease progression and prognosis. The methods of MRD diagnostics are based on detection of specific tumor markers. Of these, the most specific for lung cancer, appears to be the LunX protein. The best method for determining MRD is probably RT-PCR. Further studies should expand knowledge in this area: to refine understanding of the importance of tumor markers for prognosis, as well as to confirm the significance of these findings in clinical practice." @default.
• W2133241939 created "2016-06-24" @default.
• W2133241939 creator A5001314087 @default.
• W2133241939 creator A5016827125 @default.
• W2133241939 creator A5023049602 @default.
• W2133241939 creator A5031744194 @default.
• W2133241939 creator A5032474958 @default.
• W2133241939 creator A5036610284 @default.
• W2133241939 creator A5039806503 @default.
• W2133241939 creator A5065314384 @default.
• W2133241939 creator A5081353075 @default.
• W2133241939 creator A5091847975 @default.
• W2133241939 date "2014-06-23" @default.
• W2133241939 modified "2023-10-16" @default.
• W2133241939 title "Detection of minimal residual disease in lung cancer" @default.
• W2133241939 cites W1536740149 @default.
• W2133241939 cites W1968475252 @default.
• W2133241939 cites W1985947890 @default.
• W2133241939 cites W1990077293 @default.
• W2133241939 cites W2014647550 @default.
• W2133241939 cites W2017583911 @default.
• W2133241939 cites W2036697801 @default.
• W2133241939 cites W2083929748 @default.
• W2133241939 cites W2102806463 @default.
• W2133241939 cites W2123911518 @default.
• W2133241939 cites W2125954956 @default.
• W2133241939 cites W2126735047 @default.
• W2133241939 cites W2189916683 @default.
• W2133241939 cites W2335426249 @default.
• W2133241939 cites W4207058970 @default.
• W2133241939 cites W4243820083 @default.
• W2133241939 cites W4367590687 @default.
• W2133241939 doi "https://doi.org/10.5507/bp.2013.019" @default.
• W2133241939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23558472" @default.
• W2133241939 hasPublicationYear "2014" @default.
• W2133241939 type Work @default.
• W2133241939 sameAs 2133241939 @default.
• W2133241939 citedByCount "9" @default.
• W2133241939 countsByYear W21332419392020 @default.
• W2133241939 countsByYear W21332419392021 @default.
• W2133241939 countsByYear W21332419392022 @default.
• W2133241939 countsByYear W21332419392023 @default.
• W2133241939 crossrefType "journal-article" @default.
• W2133241939 hasAuthorship W2133241939A5001314087 @default.
• W2133241939 hasAuthorship W2133241939A5016827125 @default.
• W2133241939 hasAuthorship W2133241939A5023049602 @default.
• W2133241939 hasAuthorship W2133241939A5031744194 @default.
• W2133241939 hasAuthorship W2133241939A5032474958 @default.
• W2133241939 hasAuthorship W2133241939A5036610284 @default.
• W2133241939 hasAuthorship W2133241939A5039806503 @default.
• W2133241939 hasAuthorship W2133241939A5065314384 @default.
• W2133241939 hasAuthorship W2133241939A5081353075 @default.
• W2133241939 hasAuthorship W2133241939A5091847975 @default.
• W2133241939 hasBestOaLocation W21332419391 @default.
• W2133241939 hasConcept C113280763 @default.
• W2133241939 hasConcept C121608353 @default.
• W2133241939 hasConcept C126322002 @default.
• W2133241939 hasConcept C142724271 @default.
• W2133241939 hasConcept C143998085 @default.
• W2133241939 hasConcept C207886595 @default.
• W2133241939 hasConcept C2776256026 @default.
• W2133241939 hasConcept C2777714996 @default.
• W2133241939 hasConcept C2779134260 @default.
• W2133241939 hasConcept C2779823535 @default.
• W2133241939 hasConcept C2780007613 @default.
• W2133241939 hasConcept C71924100 @default.
• W2133241939 hasConceptScore W2133241939C113280763 @default.
• W2133241939 hasConceptScore W2133241939C121608353 @default.
• W2133241939 hasConceptScore W2133241939C126322002 @default.
• W2133241939 hasConceptScore W2133241939C142724271 @default.
• W2133241939 hasConceptScore W2133241939C143998085 @default.
• W2133241939 hasConceptScore W2133241939C207886595 @default.
• W2133241939 hasConceptScore W2133241939C2776256026 @default.
• W2133241939 hasConceptScore W2133241939C2777714996 @default.
• W2133241939 hasConceptScore W2133241939C2779134260 @default.
• W2133241939 hasConceptScore W2133241939C2779823535 @default.
• W2133241939 hasConceptScore W2133241939C2780007613 @default.
• W2133241939 hasConceptScore W2133241939C71924100 @default.
• W2133241939 hasIssue "2" @default.
• W2133241939 hasLocation W21332419391 @default.
• W2133241939 hasLocation W21332419392 @default.
• W2133241939 hasLocation W21332419393 @default.
• W2133241939 hasOpenAccess W2133241939 @default.
• W2133241939 hasPrimaryLocation W21332419391 @default.
• W2133241939 hasRelatedWork W1967103478 @default.
• W2133241939 hasRelatedWork W1970709107 @default.
• W2133241939 hasRelatedWork W2032912323 @default.
• W2133241939 hasRelatedWork W2090982939 @default.
• W2133241939 hasRelatedWork W2367850803 @default.
• W2133241939 hasRelatedWork W2372561159 @default.
• W2133241939 hasRelatedWork W2375344515 @default.
• W2133241939 hasRelatedWork W2390152934 @default.
• W2133241939 hasRelatedWork W2394277987 @default.
• W2133241939 hasRelatedWork W4238002189 @default.
• W2133241939 hasVolume "158" @default.
• W2133241939 isParatext "false" @default.
• W2133241939 isRetracted "false" @default.
• W2133241939 magId "2133241939" @default.

• next