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• W2133242615 abstract "We compared two routes for myocardial delivery of therapeutics, transendocardial (TE) delivery with an intramyocardial injection catheter, and retrograde coronary venous (RCV) delivery with a balloon occlusion catheter in the interventricular vein. Methods: TE and RCV injection of 15 μm, neutron-activatable microspheres was compared in healthy pigs (Group I, n = 3), pigs with a 1-week-old myocardial infarction (MI; group II, n = 5), and pigs with a 2-weeks-old MI (group III, n = 4). The MI was induced by a 1-hr balloon occlusion in the LAD. Both methods were compared in the same animal using different microspheres. The RCV catheter allowed for continuous measurement of distal pressure and 2.5 × 106 microspheres were injected in 10 ml at 300 mmHg above balloon occlusion pressure. The TE injections were targeted to the infarct zone and 2.5 × 106 microspheres were distributed over 10 injections of 200 μl. Results: The retention of microspheres decreased with increase in MI age, but was comparable between devices within the groups. RCV delivery resulted in (14.3 ± 0.9)% microsphere retention in Group I, (10.3 ± 0.2)% in Group II, and (6.4 ± 0.1)% in group III (P < 0.05 versus group I). Microsphere retention after TE was (15.1 ± 0.7)% in group I, (18.9 ± 0.6)% in group II, (4.1 ± 0.1)% in Group III (P < 0.05 versus groups I and II). The RCV catheter delivered primarily to midventricular, antero-septal segments, whereas TE targeted apical areas predominantly. Conclusions: Delivery efficacy was comparable between devices in each group however RCV targeted midventricular areas whereas TE targeted apical areas. © 2006 Wiley-Liss, Inc." @default.
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• W2133242615 date "2006-01-01" @default.
• W2133242615 modified "2023-10-05" @default.
• W2133242615 title "Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs" @default.
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• W2133242615 doi "https://doi.org/10.1002/ccd.20841" @default.
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