FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133244560> ?p ?o ?g. }

• W2133244560 endingPage "30" @default.
• W2133244560 startingPage "1017" @default.
• W2133244560 abstract "Protein kinase C (PKC) plays a central role in signal transduction pathways that mediate the action of certain growth factors, tumor promoters, and cellular oncogenes. To explore whether PKC might be an appropriate target for the chemotherapy of human brain tumors, cell lines were established from five glioblastomas, one mixed gliosarcoma and glioblastoma, two astrocytomas, and one choroid plexus carcinoma. The staurosporine derivative CGP 41251, an inhibitor of PKC, inhibited cell proliferation in all nine cell lines with an IC50 in the range of 0.4 micrometer. Drug withdrawal and clonogenicity assays showed that CGP 41251 induced an irreversible growth arrest. Three cell lines were examined in detail: two human glioblastoma cell lines, GB-1 and GB-2, and one gliosarcoma cell line, GS-1. All of these three cell lines were highly aneuploid and displayed morphologies and immunohistochemical markers characteristic of the glial lineage. The compound 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoter and activator of PKC, also inhibited the growth of these cell lines. CGP 41251 in combination with TPA caused further growth inhibition. Cultures treated with CGP 41251 displayed an increase in the fraction of cells in G2-M, a decrease of cells in S phase, and no consistent effect on G0-G1. Immunohistochemical analyses demonstrated that growth inhibition by CGP 41251 was associated with the formation of giant nuclei with extensive fragmentation and apoptotic bodies. These effects of CGP 41251 were abrogated by withdrawal of serum from the medium or by exposure of these cells to aphidicolin, actinomycin D, cycloheximide, or TPA. In contrast to the effects seen with the glioblastoma cell lines, nontransformed astrocyte lines remained viable in the presence of 0.4 and 0.8 micrometer CGP 41251 and displayed only a slight increase in the fraction of giant nuclei with fragmentation. The antitumor activity of CGP 41251 was demonstrated in vivo against xenografts of the glioblastoma cell lines U87 MG and U373 MG. These findings suggest that CGP 41251 might be a useful agent for the treatment of glioblastomas." @default.
• W2133244560 created "2016-06-24" @default.
• W2133244560 creator A5010928987 @default.
• W2133244560 creator A5011479527 @default.
• W2133244560 creator A5018155906 @default.
• W2133244560 creator A5023578757 @default.
• W2133244560 creator A5026614969 @default.
• W2133244560 creator A5034764013 @default.
• W2133244560 creator A5037783401 @default.
• W2133244560 creator A5044844412 @default.
• W2133244560 creator A5055848888 @default.
• W2133244560 creator A5056688284 @default.
• W2133244560 creator A5058344348 @default.
• W2133244560 creator A5059455072 @default.
• W2133244560 creator A5064708080 @default.
• W2133244560 creator A5070135380 @default.
• W2133244560 creator A5089330350 @default.
• W2133244560 date "1996-06-01" @default.
• W2133244560 modified "2023-10-10" @default.
• W2133244560 title "Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter." @default.
• W2133244560 cites W1491958169 @default.
• W2133244560 cites W1526030166 @default.
• W2133244560 cites W1580588005 @default.
• W2133244560 cites W1616213090 @default.
• W2133244560 cites W1624519387 @default.
• W2133244560 cites W1892973067 @default.
• W2133244560 cites W1915857360 @default.
• W2133244560 cites W1937458778 @default.
• W2133244560 cites W1964839077 @default.
• W2133244560 cites W1978992330 @default.
• W2133244560 cites W1993282564 @default.
• W2133244560 cites W1993968078 @default.
• W2133244560 cites W1997408971 @default.
• W2133244560 cites W1997608622 @default.
• W2133244560 cites W1999405315 @default.
• W2133244560 cites W2000669063 @default.
• W2133244560 cites W2002541809 @default.
• W2133244560 cites W2007319015 @default.
• W2133244560 cites W2015184268 @default.
• W2133244560 cites W2016363865 @default.
• W2133244560 cites W2024558939 @default.
• W2133244560 cites W2029472887 @default.
• W2133244560 cites W2041786299 @default.
• W2133244560 cites W2044949526 @default.
• W2133244560 cites W2051531396 @default.
• W2133244560 cites W2064974418 @default.
• W2133244560 cites W2068968368 @default.
• W2133244560 cites W2077813604 @default.
• W2133244560 cites W2079699191 @default.
• W2133244560 cites W2079982068 @default.
• W2133244560 cites W2080229333 @default.
• W2133244560 cites W2080275316 @default.
• W2133244560 cites W2081560586 @default.
• W2133244560 cites W2088557860 @default.
• W2133244560 cites W2092507742 @default.
• W2133244560 cites W2097829959 @default.
• W2133244560 cites W2114918609 @default.
• W2133244560 cites W2115510707 @default.
• W2133244560 cites W2115941302 @default.
• W2133244560 cites W2131528030 @default.
• W2133244560 cites W2146823703 @default.
• W2133244560 cites W2153990155 @default.
• W2133244560 cites W2166030036 @default.
• W2133244560 cites W2412338007 @default.
• W2133244560 cites W2415559638 @default.
• W2133244560 cites W2977778503 @default.
• W2133244560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9816263" @default.
• W2133244560 hasPublicationYear "1996" @default.
• W2133244560 type Work @default.
• W2133244560 sameAs 2133244560 @default.
• W2133244560 citedByCount "12" @default.
• W2133244560 crossrefType "journal-article" @default.
• W2133244560 hasAuthorship W2133244560A5010928987 @default.
• W2133244560 hasAuthorship W2133244560A5011479527 @default.
• W2133244560 hasAuthorship W2133244560A5018155906 @default.
• W2133244560 hasAuthorship W2133244560A5023578757 @default.
• W2133244560 hasAuthorship W2133244560A5026614969 @default.
• W2133244560 hasAuthorship W2133244560A5034764013 @default.
• W2133244560 hasAuthorship W2133244560A5037783401 @default.
• W2133244560 hasAuthorship W2133244560A5044844412 @default.
• W2133244560 hasAuthorship W2133244560A5055848888 @default.
• W2133244560 hasAuthorship W2133244560A5056688284 @default.
• W2133244560 hasAuthorship W2133244560A5058344348 @default.
• W2133244560 hasAuthorship W2133244560A5059455072 @default.
• W2133244560 hasAuthorship W2133244560A5064708080 @default.
• W2133244560 hasAuthorship W2133244560A5070135380 @default.
• W2133244560 hasAuthorship W2133244560A5089330350 @default.
• W2133244560 hasConcept C153911025 @default.
• W2133244560 hasConcept C190283241 @default.
• W2133244560 hasConcept C195794163 @default.
• W2133244560 hasConcept C2777168633 @default.
• W2133244560 hasConcept C2777295375 @default.
• W2133244560 hasConcept C2778128677 @default.
• W2133244560 hasConcept C2778227246 @default.
• W2133244560 hasConcept C2779084600 @default.
• W2133244560 hasConcept C2779707156 @default.
• W2133244560 hasConcept C29537977 @default.
• W2133244560 hasConcept C3017695315 @default.

• next