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• W2133265427 abstract "During the past few years, there has been exponential growth in the development of radiolabeled peptides for diagnosis and therapy. This is because the peptides can be synthesized easily and inexpensively, they have fast clearance and rapid tissue penetration, and they are less likely to be immunogenic. More importantly, most peptides have a high affinity for characteristic receptor molecules that are overexpressed on malignant mammalian cells. Peptides can be labeled with a variety of radionuclides intended for specific applications, diagnostic or therapeutic, by using both conventional and novel chelating moieties, many of which can be incorporated during the solid state synthesis of a chosen peptide. High specific-activity peptides can be prepared and used to minimize unwanted physiologic effects, and known sequences of amino acids can be modified to slow their in vivo catabolic rate. These characteristics have paved the way for the preparation of a large number of radiolabeled peptides for a variety of clinical and experimental applications. This article briefly discusses the peptide chemistry; it also summarizes the preparation of radiolabeled peptides and outlines their applications in imaging vascular thrombosis, detecting infection and inflammation, and localizing tumors. Their therapeutic applications in oncology are also presented and the future directions outlined. Peptides that have been approved for human use, such as AcuTect (Diatide, Londonderry, NH) or OctreoScan (Mallinckrodt, St. Louis, MO), or those that have made it to clinical trials, are emphasized. Also discussed are selected promising agents that are still in preclinical investigation." @default.
• W2133265427 created "2016-06-24" @default.
• W2133265427 creator A5017725276 @default.
• W2133265427 creator A5081219835 @default.
• W2133265427 date "2001-10-01" @default.
• W2133265427 modified "2023-10-07" @default.
• W2133265427 title "Radiolabeled peptides in diagnosis and therapy" @default.
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• W2133265427 doi "https://doi.org/10.1053/snuc.2001.27045" @default.
• W2133265427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11710772" @default.
• W2133265427 hasPublicationYear "2001" @default.
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