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• W2133278360 abstract "Ionizing radiation fills the universe. Daily ionizing particles and rays collide with molecules in ≈1% of the 100 trillion cells that make up the average human. These collisions generate clusters of free radicals known as reactive oxygen species that randomly damage cellular constituents including DNA (1). Certain types of ionizing radiation are more effective at generating reactive oxygen species; one α-particle is at least 10 times more damaging than one γ-ray. To take these differences into account, the Sievert (Sv), a unit that multiplies the absorbed dose in grays (Gy) by the relative effectiveness of the particle or ray to inflict damage, was developed. On this scale, natural background radiation is ≈0.01 mSv/day, although there are areas on earth that have values 5-fold higher (2), and space-station inhabitants may receive ≈1 mSv/day (3). At the other end of the scale, acute exposures of >150 mSv, a range known as high-dose radiation, have measurable and often serious immediate effects on humans (4). Between background and high-dose radiation is the range of exposures known as low-dose radiation. Low-dose radiation has no immediately noticeable effects on humans; nevertheless there is great interest in its long-term biological effects, which may include cancer in exposed individuals and genetic defects in their progeny." @default.
• W2133278360 created "2016-06-24" @default.
• W2133278360 creator A5060968786 @default.
• W2133278360 date "2003-04-18" @default.
• W2133278360 modified "2023-10-17" @default.
• W2133278360 title "Low-dose radiation: Thresholds, bystander effects, and adaptive responses" @default.
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• W2133278360 doi "https://doi.org/10.1073/pnas.1031538100" @default.
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