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• W2133278406 abstract "Iguratimod (IGU), a small-molecule compound, was developed as a disease-modifying antirheumatic drug in Japan. The pharmacological studies showed that inhibition of the production of cytokines and immunoglobulins mainly contributes to its improvement effect on animal arthritis models. The first clinical study of IGU in Japanese patients with rheumatoid arthritis was started in 1992 and Phase III studies were started in 1998. From the results of Phase II studies, a dose-escalating regimen was recommended to relieve the side effects. In a double-blind study comparing the efficacy and safety of the drug with those of placebo and salazosulfapyridine, it was confirmed that IGU was superior to placebo and was not inferior to salazosulfapyridine. Furthermore, a double-blind controlled trial of IGU in combination with methotrexate revealed an efficacious and manageable safety profile. IGU would be widely used as a new option for rheumatoid arthritis treatment and combination drug with methotrexate." @default.
• W2133278406 created "2016-06-24" @default.
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• W2133278406 date "2015-03-22" @default.
• W2133278406 modified "2023-10-02" @default.
• W2133278406 title "Iguratimod for the treatment of rheumatoid arthritis in Japan" @default.
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• W2133278406 doi "https://doi.org/10.1586/1744666x.2015.1027151" @default.
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