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• W2133281306 abstract "ABSTRACT Host defense against Mycobacterium leprae infection is chiefly mediated by gamma interferon (IFN-γ)-secreting cytotoxic T cells. Since which antigen-presenting cell populations act to stimulate these T cells is not fully understood, we addressed the role of monocyte-derived dendritic cells (DCs). The DCs phagocytosed M. leprae and expressed bacterially derived antigens (Ags), such as phenolic glycolipid 1 (PGL-1), in the cytoplasm, as well as on the cell surface. The expression of HLA-ABC and -DR Ags on DCs was down-regulated by M. leprae infection, and that of CD86 was up-regulated, but not as fully as by Mycobacterium bovis BCG infection. Induction of CD83 expression required a large number of M. leprae cells. When a multiplicity of infection of >40 was used, the DCs induced a significant proliferative and IFN-γ-producing response in autologous T cells. However, these responses were significantly lower than those induced by BCG- or Mycobacterium avium -infected DCs. A CD40-mediated signaling in M. leprae -infected DCs up-regulated the expression of HLA Ags, CD86, and CD83 but did not enhance T-cell-stimulating ability. Therefore, M. leprae -infected DCs are less efficient at inducing T-cell responses. However, when the surface PGL-1 on M. leprae -infected DCs was masked by a monoclonal antibody, the DCs induced enhanced responses in both CD4 + - and CD8 + -T-cell subsets. M. leprae is a unique pathogen which remains resistant to DC-mediated T-cell immunity, at least in the early stages of infection." @default.
• W2133281306 created "2016-06-24" @default.
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• W2133281306 date "2002-09-01" @default.
• W2133281306 modified "2023-09-25" @default.
• W2133281306 title "<i>Mycobacterium leprae</i>Infection in Monocyte-Derived Dendritic Cells and Its Influence on Antigen-Presenting Function" @default.
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• W2133281306 doi "https://doi.org/10.1128/iai.70.9.5167-5176.2002" @default.
• W2133281306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/128241" @default.
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