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- W2133282365 endingPage "e50699" @default.
- W2133282365 startingPage "e50699" @default.
- W2133282365 abstract "Campylobacter jejuni is a major cause of food-borne disease in industrialized countries. Carbohydrate utilization by C. jejuni is severely restricted, and knowledge about which substrates fuel C. jejuni infection and growth is limited. Some amino acids have been shown to serve as carbon sources both in vitro and in vivo. In the present study we investigated the contribution of serine and proline catabolism to the invitro and invivo growth of C. jejuni 81-176. We confirmed that the serine transporter SdaC and the serine ammonia-lyase SdaA are required for serine utilization, and demonstrated that a predicted proline permease PutP and a bifunctional proline/delta-1-pyrroline-5-carboxylate dehydrogenase PutA are required for proline utilization by C. jejuni 81-176. C. jejuni 81-176 mutants unable to utilize serine were shown to be severely defective for colonization of the intestine and systemic tissues in a mouse model of infection. In contrast, C. jejuni 81-176 mutants unable to utilize proline were only defective for intestinal colonization. These results further emphasize the importance of amino acid utilization in C. jejuni colonization of various tissues." @default.
- W2133282365 created "2016-06-24" @default.
- W2133282365 creator A5011227731 @default.
- W2133282365 creator A5016995233 @default.
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- W2133282365 creator A5072655809 @default.
- W2133282365 creator A5081742824 @default.
- W2133282365 date "2012-11-30" @default.
- W2133282365 modified "2023-09-25" @default.
- W2133282365 title "Contribution of Amino Acid Catabolism to the Tissue Specific Persistence of Campylobacter jejuni in a Murine Colonization Model" @default.
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