FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133284857> ?p ?o ?g. }

• W2133284857 endingPage "750" @default.
• W2133284857 startingPage "739" @default.
• W2133284857 abstract "Here we explore the activation mechanisms of human TRPC5, a putative cationic channel that was cloned from a region of the X chromosome associated with mental retardation. No basal activity was evident but activity was induced by carbachol stimulation of muscarinic receptors independently of Ca 2+ release. This is ‘receptor activation’, as described for mouse TRPC5. In addition, and in the absence of receptor stimulation, extracellular gadolinium (0.1 m m ) activated TRPC5, an effect that was mimicked by 5–20 m m extracellular Ca 2+ with intracellular Ca 2+ buffered. We refer to this as ‘external ionic activation’. TRPC5 was also activated by modest elevation of [Ca 2+ ] i in the absence of GTP –‘calcium activation’. A putative fourth activation mechanism is a signal from depleted intracellular Ca 2+ stores. Consistent with this idea, human TRPC5 was activated by a standard store‐depletion/Ca 2+ re‐entry protocol, an effect that was difficult to explain by calcium activation. Multiplicity of TRPC5 activation was demonstrated in single cells and thus not dependent on heterogeneity of expression levels or cellular context. Therefore, human TRPC5 is activated by a range of stimuli, avoiding dependence on a single critical activator as in many other ion channels. One of these stimuli would seem to be a change in Ca 2+ handling by the endoplasmic reticulum." @default.
• W2133284857 created "2016-06-24" @default.
• W2133284857 creator A5005760111 @default.
• W2133284857 creator A5010892830 @default.
• W2133284857 creator A5027312074 @default.
• W2133284857 creator A5028173765 @default.
• W2133284857 creator A5034761384 @default.
• W2133284857 creator A5042574986 @default.
• W2133284857 creator A5054706146 @default.
• W2133284857 date "2004-09-01" @default.
• W2133284857 modified "2023-10-15" @default.
• W2133284857 title "Human TRPC5 channel activated by a multiplicity of signals in a single cell" @default.
• W2133284857 cites W1980517899 @default.
• W2133284857 cites W1982486909 @default.
• W2133284857 cites W1982861469 @default.
• W2133284857 cites W1991941130 @default.
• W2133284857 cites W1993582195 @default.
• W2133284857 cites W1993886090 @default.
• W2133284857 cites W1997403199 @default.
• W2133284857 cites W2002910372 @default.
• W2133284857 cites W2006027132 @default.
• W2133284857 cites W2008714195 @default.
• W2133284857 cites W2013715844 @default.
• W2133284857 cites W2020423458 @default.
• W2133284857 cites W2023966975 @default.
• W2133284857 cites W2028175193 @default.
• W2133284857 cites W2031943544 @default.
• W2133284857 cites W2036145275 @default.
• W2133284857 cites W2037916899 @default.
• W2133284857 cites W2040664792 @default.
• W2133284857 cites W2041690080 @default.
• W2133284857 cites W2043217287 @default.
• W2133284857 cites W2043816861 @default.
• W2133284857 cites W2055307687 @default.
• W2133284857 cites W2061406577 @default.
• W2133284857 cites W2063535351 @default.
• W2133284857 cites W2065256692 @default.
• W2133284857 cites W2070010954 @default.
• W2133284857 cites W2090862432 @default.
• W2133284857 cites W2098318544 @default.
• W2133284857 cites W2102204826 @default.
• W2133284857 cites W2111443657 @default.
• W2133284857 cites W2113921063 @default.
• W2133284857 cites W2117519515 @default.
• W2133284857 cites W2119589189 @default.
• W2133284857 cites W2135567029 @default.
• W2133284857 cites W2137883612 @default.
• W2133284857 cites W2144950544 @default.
• W2133284857 cites W2150091977 @default.
• W2133284857 cites W2158754769 @default.
• W2133284857 cites W2161440135 @default.
• W2133284857 cites W2162970979 @default.
• W2133284857 cites W2164492968 @default.
• W2133284857 cites W2170542169 @default.
• W2133284857 cites W2220650403 @default.
• W2133284857 doi "https://doi.org/10.1113/jphysiol.2004.065391" @default.
• W2133284857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1665180" @default.
• W2133284857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15254149" @default.
• W2133284857 hasPublicationYear "2004" @default.
• W2133284857 type Work @default.
• W2133284857 sameAs 2133284857 @default.
• W2133284857 citedByCount "124" @default.
• W2133284857 countsByYear W21332848572012 @default.
• W2133284857 countsByYear W21332848572013 @default.
• W2133284857 countsByYear W21332848572014 @default.
• W2133284857 countsByYear W21332848572015 @default.
• W2133284857 countsByYear W21332848572016 @default.
• W2133284857 countsByYear W21332848572017 @default.
• W2133284857 countsByYear W21332848572018 @default.
• W2133284857 countsByYear W21332848572019 @default.
• W2133284857 countsByYear W21332848572020 @default.
• W2133284857 countsByYear W21332848572021 @default.
• W2133284857 countsByYear W21332848572022 @default.
• W2133284857 countsByYear W21332848572023 @default.
• W2133284857 crossrefType "journal-article" @default.
• W2133284857 hasAuthorship W2133284857A5005760111 @default.
• W2133284857 hasAuthorship W2133284857A5010892830 @default.
• W2133284857 hasAuthorship W2133284857A5027312074 @default.
• W2133284857 hasAuthorship W2133284857A5028173765 @default.
• W2133284857 hasAuthorship W2133284857A5034761384 @default.
• W2133284857 hasAuthorship W2133284857A5042574986 @default.
• W2133284857 hasAuthorship W2133284857A5054706146 @default.
• W2133284857 hasBestOaLocation W21332848572 @default.
• W2133284857 hasConcept C12554922 @default.
• W2133284857 hasConcept C155164980 @default.
• W2133284857 hasConcept C170488646 @default.
• W2133284857 hasConcept C170493617 @default.
• W2133284857 hasConcept C185592680 @default.
• W2133284857 hasConcept C196156954 @default.
• W2133284857 hasConcept C2778988552 @default.
• W2133284857 hasConcept C28406088 @default.
• W2133284857 hasConcept C55493867 @default.
• W2133284857 hasConcept C86803240 @default.
• W2133284857 hasConcept C95444343 @default.
• W2133284857 hasConceptScore W2133284857C12554922 @default.
• W2133284857 hasConceptScore W2133284857C155164980 @default.
• W2133284857 hasConceptScore W2133284857C170488646 @default.
• W2133284857 hasConceptScore W2133284857C170493617 @default.

• next