Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133291978> ?p ?o ?g. }
- W2133291978 endingPage "387" @default.
- W2133291978 startingPage "374" @default.
- W2133291978 abstract "The endogenous cannabinoid system is involved in the regulation of the central reward pathway. Running wheel and sucrose consumption have rewarding and reinforcing properties in rodents, and share many neurochemical and behavioral characteristics with drug addiction. In this study, we investigated whether running wheel or sucrose consumption altered the sensitivity of striatal synapses to the activation of cannabinoid CB1 receptors. We found that cannabinoid CB1 receptor-mediated presynaptic control of striatal inhibitory postsynaptic currents was remarkably potentiated after these environmental manipulations. In contrast, the sensitivity of glutamate synapses to CB1 receptor stimulation was unaltered, as well as that of GABA synapses to the stimulation of presynaptic GABAB receptors. The sensitization of cannabinoid CB1 receptor-mediated responses was slowly reversible after the discontinuation of running wheel or sucrose consumption, and was also detectable following the mobilization of endocannabinoids by metabotropic glutamate receptor 5 stimulation. Finally, we found that the upregulation of cannabinoid transmission induced by wheel running or sucrose had a crucial role in the protective effects of these environmental manipulations against the motor and synaptic consequences of stress." @default.
- W2133291978 created "2016-06-24" @default.
- W2133291978 creator A5001899447 @default.
- W2133291978 creator A5004532849 @default.
- W2133291978 creator A5006126677 @default.
- W2133291978 creator A5008399113 @default.
- W2133291978 creator A5009556398 @default.
- W2133291978 creator A5009558012 @default.
- W2133291978 creator A5021429755 @default.
- W2133291978 creator A5031150849 @default.
- W2133291978 creator A5041838697 @default.
- W2133291978 creator A5051741927 @default.
- W2133291978 creator A5067324265 @default.
- W2133291978 creator A5079049956 @default.
- W2133291978 date "2009-09-23" @default.
- W2133291978 modified "2023-10-15" @default.
- W2133291978 title "Voluntary Exercise and Sucrose Consumption Enhance Cannabinoid CB1 Receptor Sensitivity in the Striatum" @default.
- W2133291978 cites W1513230591 @default.
- W2133291978 cites W1534301864 @default.
- W2133291978 cites W1905669859 @default.
- W2133291978 cites W1945424073 @default.
- W2133291978 cites W1971522104 @default.
- W2133291978 cites W1972482412 @default.
- W2133291978 cites W1973647403 @default.
- W2133291978 cites W1978019127 @default.
- W2133291978 cites W1979009659 @default.
- W2133291978 cites W1979315934 @default.
- W2133291978 cites W1984788277 @default.
- W2133291978 cites W1985355840 @default.
- W2133291978 cites W1988633467 @default.
- W2133291978 cites W1993109240 @default.
- W2133291978 cites W1998335883 @default.
- W2133291978 cites W2000363595 @default.
- W2133291978 cites W2006926071 @default.
- W2133291978 cites W2007064781 @default.
- W2133291978 cites W2011668852 @default.
- W2133291978 cites W2022402243 @default.
- W2133291978 cites W2022696445 @default.
- W2133291978 cites W2026633568 @default.
- W2133291978 cites W2030276643 @default.
- W2133291978 cites W2030687244 @default.
- W2133291978 cites W2031014067 @default.
- W2133291978 cites W2032808929 @default.
- W2133291978 cites W2037184447 @default.
- W2133291978 cites W2039924325 @default.
- W2133291978 cites W2040051923 @default.
- W2133291978 cites W2042587343 @default.
- W2133291978 cites W2043828632 @default.
- W2133291978 cites W2045417829 @default.
- W2133291978 cites W2051640748 @default.
- W2133291978 cites W2054090721 @default.
- W2133291978 cites W2054203254 @default.
- W2133291978 cites W2054863711 @default.
- W2133291978 cites W2055981668 @default.
- W2133291978 cites W2059079970 @default.
- W2133291978 cites W2062367401 @default.
- W2133291978 cites W2079810105 @default.
- W2133291978 cites W2080349415 @default.
- W2133291978 cites W2085121914 @default.
- W2133291978 cites W2085314208 @default.
- W2133291978 cites W2086169831 @default.
- W2133291978 cites W2086781281 @default.
- W2133291978 cites W2088891858 @default.
- W2133291978 cites W2091447309 @default.
- W2133291978 cites W2093137269 @default.
- W2133291978 cites W2094300440 @default.
- W2133291978 cites W2096012985 @default.
- W2133291978 cites W2108502510 @default.
- W2133291978 cites W2111038577 @default.
- W2133291978 cites W2111689088 @default.
- W2133291978 cites W2112213092 @default.
- W2133291978 cites W2112643649 @default.
- W2133291978 cites W2115444744 @default.
- W2133291978 cites W2117464894 @default.
- W2133291978 cites W2124276340 @default.
- W2133291978 cites W2142013939 @default.
- W2133291978 cites W2148625659 @default.
- W2133291978 cites W2153722042 @default.
- W2133291978 cites W2156883930 @default.
- W2133291978 cites W2160215480 @default.
- W2133291978 cites W2165398609 @default.
- W2133291978 cites W2168882723 @default.
- W2133291978 cites W2171584675 @default.
- W2133291978 cites W2172010489 @default.
- W2133291978 cites W2285870167 @default.
- W2133291978 cites W4321429251 @default.
- W2133291978 doi "https://doi.org/10.1038/npp.2009.141" @default.
- W2133291978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055381" @default.
- W2133291978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19776732" @default.
- W2133291978 hasPublicationYear "2009" @default.
- W2133291978 type Work @default.
- W2133291978 sameAs 2133291978 @default.
- W2133291978 citedByCount "72" @default.
- W2133291978 countsByYear W21332919782012 @default.
- W2133291978 countsByYear W21332919782013 @default.
- W2133291978 countsByYear W21332919782014 @default.
- W2133291978 countsByYear W21332919782015 @default.
- W2133291978 countsByYear W21332919782016 @default.