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- W2133294507 abstract "Ipilimumab is the prototypical immunomodulatory antibody, approved by the FDA in 2011 for advanced melanoma on the basis of survival benefit. Since that time, we have made significant strides in optimizing this therapy: we have characterized the spectrum of immune-related adverse events and learned how to mitigate them with treatment algorithms, discovered potential biomarkers of activity, and identified the potential synergy between checkpoint modulation and other therapeutic modalities. Recent phase I trials have established the efficacy and safety of next-generation checkpoint agents, including PD-1 and PD-L1 inhibitors, across multiple tumor types. Much work lies ahead in developing these next-generation checkpoint agents, testing them in combination, and determining how to integrate them into the treatment paradigms of various tumor types." @default.
- W2133294507 created "2016-06-24" @default.
- W2133294507 creator A5011114578 @default.
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- W2133294507 creator A5017531113 @default.
- W2133294507 creator A5047117233 @default.
- W2133294507 creator A5054656505 @default.
- W2133294507 date "2014-01-14" @default.
- W2133294507 modified "2023-10-10" @default.
- W2133294507 title "Immune Modulation in Cancer with Antibodies" @default.
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