FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133326578> ?p ?o ?g. }

• W2133326578 endingPage "390" @default.
• W2133326578 startingPage "383" @default.
• W2133326578 abstract "The objective of this study was to determine whether aberrant hepatic expression of cytokeratin 7 (CK7) and/or other putative stem cell markers is seen in pediatric cholestatic diseases. Eighteen liver biopsies and 14 liver explants from pediatric patients with extrahepatic biliary atresia (EHBA), Alagille syndrome (AGS), primary sclerosing cholangitis (PSC), inborn errors of bile acid synthesis, and progressive familial intrahepatic cholestasis (PFIC) were examined along with 5 histologically normal control liver biopsies. Immumohistochemical stains (CK7, CD56, and OV6) were performed on paraffin-embedded tissue. Staining of interlobular bile ducts (ILBD), proliferating bile ductules, and hepatocytes was scored using a semiquantitative scale. There were significant differences in CK7 staining of hepatocytes among the cholestatic diseases ( P < 0.006). All cases with AGS showed CK7 hepatocyte staining, while EHBA and PSC had variable hepatocyte staining. Patients with PFIC had prominent CK7 hepatocyte staining, while those with inborn errors of bile acid synthesis had little. Control biopsies showed rare hepatocyte staining. Analysis based on the presence or absence of ILBD revealed significantly more CK7 hepatocyte staining in cases with loss of ILBD ( P < 0.001). CD56 staining of hepatocytes was also present more frequently in cases with absent or reduced ILBD. Regardless of underlying disease, loss of ILBD is a major determinant of aberrant expression of CK7 by hepatocytes. Aberrant CK7 expression may reflect a metaplastic change to a “stem cell” phenotype induced by loss of contact with the more distal biliary tree." @default.
• W2133326578 created "2016-06-24" @default.
• W2133326578 creator A5016600086 @default.
• W2133326578 creator A5028020710 @default.
• W2133326578 creator A5029480768 @default.
• W2133326578 creator A5053363242 @default.
• W2133326578 creator A5060544555 @default.
• W2133326578 date "2007-09-01" @default.
• W2133326578 modified "2023-10-14" @default.
• W2133326578 title "Interlobular Bile Duct Loss in Pediatric Cholestatic Disease is Associated with Aberrant Cytokeratin 7 Expression by Hepatocytes" @default.
• W2133326578 cites W1795586814 @default.
• W2133326578 cites W1900911764 @default.
• W2133326578 cites W1969891144 @default.
• W2133326578 cites W1978857300 @default.
• W2133326578 cites W1979145337 @default.
• W2133326578 cites W1985817936 @default.
• W2133326578 cites W2015950273 @default.
• W2133326578 cites W2017697108 @default.
• W2133326578 cites W2035896849 @default.
• W2133326578 cites W2036317641 @default.
• W2133326578 cites W2041986497 @default.
• W2133326578 cites W2090557152 @default.
• W2133326578 cites W2092743512 @default.
• W2133326578 cites W2100521893 @default.
• W2133326578 cites W2162179363 @default.
• W2133326578 cites W2168362482 @default.
• W2133326578 cites W2521880154 @default.
• W2133326578 cites W4322701961 @default.
• W2133326578 doi "https://doi.org/10.2350/06-09-0171.1" @default.
• W2133326578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17929991" @default.
• W2133326578 hasPublicationYear "2007" @default.
• W2133326578 type Work @default.
• W2133326578 sameAs 2133326578 @default.
• W2133326578 citedByCount "26" @default.
• W2133326578 countsByYear W21333265782013 @default.
• W2133326578 countsByYear W21333265782014 @default.
• W2133326578 countsByYear W21333265782015 @default.
• W2133326578 countsByYear W21333265782017 @default.
• W2133326578 countsByYear W21333265782018 @default.
• W2133326578 countsByYear W21333265782019 @default.
• W2133326578 countsByYear W21333265782020 @default.
• W2133326578 countsByYear W21333265782021 @default.
• W2133326578 countsByYear W21333265782022 @default.
• W2133326578 countsByYear W21333265782023 @default.
• W2133326578 crossrefType "journal-article" @default.
• W2133326578 hasAuthorship W2133326578A5016600086 @default.
• W2133326578 hasAuthorship W2133326578A5028020710 @default.
• W2133326578 hasAuthorship W2133326578A5029480768 @default.
• W2133326578 hasAuthorship W2133326578A5053363242 @default.
• W2133326578 hasAuthorship W2133326578A5060544555 @default.
• W2133326578 hasConcept C126322002 @default.
• W2133326578 hasConcept C142724271 @default.
• W2133326578 hasConcept C202751555 @default.
• W2133326578 hasConcept C204232928 @default.
• W2133326578 hasConcept C2776200302 @default.
• W2133326578 hasConcept C2778132995 @default.
• W2133326578 hasConcept C2778593092 @default.
• W2133326578 hasConcept C2779012181 @default.
• W2133326578 hasConcept C2779134260 @default.
• W2133326578 hasConcept C2779243279 @default.
• W2133326578 hasConcept C2779399885 @default.
• W2133326578 hasConcept C2779609443 @default.
• W2133326578 hasConcept C2779777945 @default.
• W2133326578 hasConcept C2780615123 @default.
• W2133326578 hasConcept C2780788601 @default.
• W2133326578 hasConcept C2780971011 @default.
• W2133326578 hasConcept C2910364697 @default.
• W2133326578 hasConcept C2911091166 @default.
• W2133326578 hasConcept C55493867 @default.
• W2133326578 hasConcept C71924100 @default.
• W2133326578 hasConcept C74864618 @default.
• W2133326578 hasConcept C86803240 @default.
• W2133326578 hasConceptScore W2133326578C126322002 @default.
• W2133326578 hasConceptScore W2133326578C142724271 @default.
• W2133326578 hasConceptScore W2133326578C202751555 @default.
• W2133326578 hasConceptScore W2133326578C204232928 @default.
• W2133326578 hasConceptScore W2133326578C2776200302 @default.
• W2133326578 hasConceptScore W2133326578C2778132995 @default.
• W2133326578 hasConceptScore W2133326578C2778593092 @default.
• W2133326578 hasConceptScore W2133326578C2779012181 @default.
• W2133326578 hasConceptScore W2133326578C2779134260 @default.
• W2133326578 hasConceptScore W2133326578C2779243279 @default.
• W2133326578 hasConceptScore W2133326578C2779399885 @default.
• W2133326578 hasConceptScore W2133326578C2779609443 @default.
• W2133326578 hasConceptScore W2133326578C2779777945 @default.
• W2133326578 hasConceptScore W2133326578C2780615123 @default.
• W2133326578 hasConceptScore W2133326578C2780788601 @default.
• W2133326578 hasConceptScore W2133326578C2780971011 @default.
• W2133326578 hasConceptScore W2133326578C2910364697 @default.
• W2133326578 hasConceptScore W2133326578C2911091166 @default.
• W2133326578 hasConceptScore W2133326578C55493867 @default.
• W2133326578 hasConceptScore W2133326578C71924100 @default.
• W2133326578 hasConceptScore W2133326578C74864618 @default.
• W2133326578 hasConceptScore W2133326578C86803240 @default.
• W2133326578 hasIssue "5" @default.
• W2133326578 hasLocation W21333265781 @default.
• W2133326578 hasLocation W21333265782 @default.
• W2133326578 hasOpenAccess W2133326578 @default.

• next