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• W2133333494 endingPage "738" @default.
• W2133333494 startingPage "733" @default.
• W2133333494 abstract "Summary Individuals belonging to six racial groups (African American, Asian Indian, Caucasian, Hispanic, Korean, Native American), and a seventh group comprised of referred patients with thrombosis were genotyped for the prothrombin G20210A mutation, the factor V G1691A (Leiden) mutation, and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation by multiplexed allele-specific PCR. The prothrombin 20210A and factor V 1691A allele frequencies in the thrombosis patients, 3.2% and 9.5%, were significantly higher than those in the random Caucasians, 1.3% and 1.8%, (p = 0.043 and p <0.001, respectively). The relative risk of venous thrombosis was determined to be 2.4-fold for carriers of the prothrombin 20210A allele (odds ratio = 2.54; 95% confidence interval = 0.94, 6.82) and 4.5-fold for carriers of the factor V 1691A allele (odds ratio = 5.06; 95% confidence interval = 2.25, 11.36). Among the seven populations, significant differences were observed in the MTHFR 677T allele distribution, however this mutation was not determined to be a risk factor for venous thrombosis in the patient group studied, either alone or in combination with the pro-thrombin 20210A and/or the factor V 1691A allele(s)." @default.
• W2133333494 created "2016-06-24" @default.
• W2133333494 creator A5034542132 @default.
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• W2133333494 date "1999-01-01" @default.
• W2133333494 modified "2023-09-27" @default.
• W2133333494 title "Prevalence of Prothrombin G20210A, Factor V G1691A (Leiden), and Methylenetetrahydrofolate Reductase (MTHFR) C677T in Seven Different Populations Determined by Multiplex Allele-specific PCR" @default.
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• W2133333494 doi "https://doi.org/10.1055/s-0037-1614563" @default.
• W2133333494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10365746" @default.
• W2133333494 hasPublicationYear "1999" @default.
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