FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133346314> ?p ?o ?g. }

• W2133346314 endingPage "1550" @default.
• W2133346314 startingPage "1544" @default.
• W2133346314 abstract "Enzymatically glycosylated proteins partake in multiple biological processes, including glucose transport and inflammation. We hypothesized that a novel biomarker (GlycA) of N-acetyl methyl groups originating mainly from N-acetylglucosamine moieties of acute-phase glycoproteins is related to incident type 2 diabetes mellitus and compared it with high-sensitivity C-reactive protein.In 26,508 initially healthy women free of diabetes mellitus, baseline GlycA and high-sensitivity C-reactive protein were quantified by nuclear magnetic resonance spectroscopy and immunoturbidimetry, respectively. During median follow-up of 17.2 years, 2087 type 2 diabetes mellitus cases occurred. In Cox models with adjustment for age, race, smoking, alcohol, activity, menopausal status, hormone use, family history, and body mass index, quartile 4 versus 1 hazard ratios and 95% confidence intervals were 2.67 (2.26-3.14) for GlycA and 3.93 (3.24-4.77) for high-sensitivity C-reactive protein; both P trend <0.0001. Associations for GlycA and high-sensitivity C-reactive protein were attenuated after additionally adjusting for lipids: 1.65 (1.39-1.95) and 2.83 (2.32-3.44), respectively, both P trend <0.0001, and after mutual adjustment: 1.11 (0.93-1.33; P trend=0.10) and 2.57 (2.09-3.16; P trend<0.0001), respectively.Our finding of an association between a consensus glycan sequence common to a host of acute-phase reactants and incident type 2 diabetes mellitus provides further support for inflammation in the development of type 2 diabetes mellitus. Additional studies exploring the role of enzymatic glycosylation in the prevention of type 2 diabetes mellitus are warranted.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00000479." @default.
• W2133346314 created "2016-06-24" @default.
• W2133346314 creator A5015295498 @default.
• W2133346314 creator A5045857025 @default.
• W2133346314 creator A5074749823 @default.
• W2133346314 creator A5090744975 @default.
• W2133346314 creator A5091595592 @default.
• W2133346314 date "2015-06-01" @default.
• W2133346314 modified "2023-10-11" @default.
• W2133346314 title "Novel Protein Glycan Side-Chain Biomarker and Risk of Incident Type 2 Diabetes Mellitus" @default.
• W2133346314 cites W1600300638 @default.
• W2133346314 cites W1735966469 @default.
• W2133346314 cites W1968014420 @default.
• W2133346314 cites W1994988956 @default.
• W2133346314 cites W2018135697 @default.
• W2133346314 cites W2019859514 @default.
• W2133346314 cites W2021343620 @default.
• W2133346314 cites W2023863507 @default.
• W2133346314 cites W2024191848 @default.
• W2133346314 cites W2024378513 @default.
• W2133346314 cites W2031980199 @default.
• W2133346314 cites W2044437167 @default.
• W2133346314 cites W2061725473 @default.
• W2133346314 cites W2066744262 @default.
• W2133346314 cites W2115819915 @default.
• W2133346314 cites W2128290503 @default.
• W2133346314 cites W2130585857 @default.
• W2133346314 cites W2132455905 @default.
• W2133346314 cites W2142213104 @default.
• W2133346314 cites W2142574184 @default.
• W2133346314 cites W2146756601 @default.
• W2133346314 cites W2157307940 @default.
• W2133346314 cites W2160115185 @default.
• W2133346314 cites W4300695220 @default.
• W2133346314 doi "https://doi.org/10.1161/atvbaha.115.305635" @default.
• W2133346314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4441588" @default.
• W2133346314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25908766" @default.
• W2133346314 hasPublicationYear "2015" @default.
• W2133346314 type Work @default.
• W2133346314 sameAs 2133346314 @default.
• W2133346314 citedByCount "98" @default.
• W2133346314 countsByYear W21333463142015 @default.
• W2133346314 countsByYear W21333463142016 @default.
• W2133346314 countsByYear W21333463142017 @default.
• W2133346314 countsByYear W21333463142018 @default.
• W2133346314 countsByYear W21333463142019 @default.
• W2133346314 countsByYear W21333463142020 @default.
• W2133346314 countsByYear W21333463142021 @default.
• W2133346314 countsByYear W21333463142022 @default.
• W2133346314 countsByYear W21333463142023 @default.
• W2133346314 crossrefType "journal-article" @default.
• W2133346314 hasAuthorship W2133346314A5015295498 @default.
• W2133346314 hasAuthorship W2133346314A5045857025 @default.
• W2133346314 hasAuthorship W2133346314A5074749823 @default.
• W2133346314 hasAuthorship W2133346314A5090744975 @default.
• W2133346314 hasAuthorship W2133346314A5091595592 @default.
• W2133346314 hasBestOaLocation W21333463141 @default.
• W2133346314 hasConcept C126322002 @default.
• W2133346314 hasConcept C134018914 @default.
• W2133346314 hasConcept C185592680 @default.
• W2133346314 hasConcept C207103383 @default.
• W2133346314 hasConcept C2776914184 @default.
• W2133346314 hasConcept C2777180221 @default.
• W2133346314 hasConcept C2780221984 @default.
• W2133346314 hasConcept C2781195455 @default.
• W2133346314 hasConcept C2781197716 @default.
• W2133346314 hasConcept C2910068830 @default.
• W2133346314 hasConcept C44249647 @default.
• W2133346314 hasConcept C55493867 @default.
• W2133346314 hasConcept C555293320 @default.
• W2133346314 hasConcept C68443243 @default.
• W2133346314 hasConcept C71924100 @default.
• W2133346314 hasConcept C90924648 @default.
• W2133346314 hasConceptScore W2133346314C126322002 @default.
• W2133346314 hasConceptScore W2133346314C134018914 @default.
• W2133346314 hasConceptScore W2133346314C185592680 @default.
• W2133346314 hasConceptScore W2133346314C207103383 @default.
• W2133346314 hasConceptScore W2133346314C2776914184 @default.
• W2133346314 hasConceptScore W2133346314C2777180221 @default.
• W2133346314 hasConceptScore W2133346314C2780221984 @default.
• W2133346314 hasConceptScore W2133346314C2781195455 @default.
• W2133346314 hasConceptScore W2133346314C2781197716 @default.
• W2133346314 hasConceptScore W2133346314C2910068830 @default.
• W2133346314 hasConceptScore W2133346314C44249647 @default.
• W2133346314 hasConceptScore W2133346314C55493867 @default.
• W2133346314 hasConceptScore W2133346314C555293320 @default.
• W2133346314 hasConceptScore W2133346314C68443243 @default.
• W2133346314 hasConceptScore W2133346314C71924100 @default.
• W2133346314 hasConceptScore W2133346314C90924648 @default.
• W2133346314 hasIssue "6" @default.
• W2133346314 hasLocation W21333463141 @default.
• W2133346314 hasLocation W21333463142 @default.
• W2133346314 hasLocation W21333463143 @default.
• W2133346314 hasLocation W21333463144 @default.
• W2133346314 hasOpenAccess W2133346314 @default.
• W2133346314 hasPrimaryLocation W21333463141 @default.
• W2133346314 hasRelatedWork W1992800610 @default.
• W2133346314 hasRelatedWork W2003150205 @default.

• next