FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133361341> ?p ?o ?g. }

• W2133361341 endingPage "3821" @default.
• W2133361341 startingPage "3805" @default.
• W2133361341 abstract "The hereditary spastic paraplegias (HSPs) are genetic conditions characterized by distal axonopathy of the longest corticospinal tract axons, and so their study provides an important opportunity to understand mechanisms involved in axonal maintenance and degeneration. A group of HSP genes encode proteins that localize to endosomes. One of these is NIPA1 (non-imprinted in Prader-Willi/Angelman syndrome 1) and we have shown recently that its Drosophila homologue spichthyin inhibits bone morphogenic protein (BMP) signalling, although the relevance of this finding to the mammalian protein was not known. We show here that mammalian NIPA1 is also an inhibitor of BMP signalling. NIPA1 physically interacts with the type II BMP receptor (BMPRII) and we demonstrate that this interaction does not require the cytoplasmic tail of BMPRII. We show that the mechanism by which NIPA1 inhibits BMP signalling involves downregulation of BMP receptors by promoting their endocytosis and lysosomal degradation. Disease-associated mutant versions of NIPA1 alter the trafficking of BMPRII and are less efficient at promoting BMPRII degradation than wild-type NIPA1. In addition, we demonstrate that two other members of the endosomal group of HSP proteins, spastin and spartin, are inhibitors of BMP signalling. Since BMP signalling is important for distal axonal function, we propose that dysregulation of BMP signalling could be a unifying pathological component in this endosomal group of HSPs, and perhaps of importance in other conditions in which distal axonal degeneration is found." @default.
• W2133361341 created "2016-06-24" @default.
• W2133361341 creator A5009267002 @default.
• W2133361341 creator A5035887146 @default.
• W2133361341 creator A5036804333 @default.
• W2133361341 creator A5043458784 @default.
• W2133361341 creator A5049886632 @default.
• W2133361341 creator A5056838899 @default.
• W2133361341 creator A5089695450 @default.
• W2133361341 creator A5089747405 @default.
• W2133361341 creator A5091405504 @default.
• W2133361341 date "2009-07-20" @default.
• W2133361341 modified "2023-10-10" @default.
• W2133361341 title "The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling" @default.
• W2133361341 cites W1498629854 @default.
• W2133361341 cites W1594381485 @default.
• W2133361341 cites W1826848447 @default.
• W2133361341 cites W1968323673 @default.
• W2133361341 cites W1969465539 @default.
• W2133361341 cites W1971339863 @default.
• W2133361341 cites W1979904143 @default.
• W2133361341 cites W1983685921 @default.
• W2133361341 cites W1986354685 @default.
• W2133361341 cites W1988639783 @default.
• W2133361341 cites W1994099986 @default.
• W2133361341 cites W1999110803 @default.
• W2133361341 cites W2001544293 @default.
• W2133361341 cites W2006176190 @default.
• W2133361341 cites W2009495477 @default.
• W2133361341 cites W2010233410 @default.
• W2133361341 cites W2014263971 @default.
• W2133361341 cites W2016324935 @default.
• W2133361341 cites W2018879436 @default.
• W2133361341 cites W2021981560 @default.
• W2133361341 cites W2026360271 @default.
• W2133361341 cites W2032444338 @default.
• W2133361341 cites W2040891140 @default.
• W2133361341 cites W2044643509 @default.
• W2133361341 cites W2046128749 @default.
• W2133361341 cites W2056085466 @default.
• W2133361341 cites W2066252692 @default.
• W2133361341 cites W2066939817 @default.
• W2133361341 cites W2073637383 @default.
• W2133361341 cites W2076745544 @default.
• W2133361341 cites W2091063567 @default.
• W2133361341 cites W2105068259 @default.
• W2133361341 cites W2110378485 @default.
• W2133361341 cites W2115102669 @default.
• W2133361341 cites W2128603782 @default.
• W2133361341 cites W2130326770 @default.
• W2133361341 cites W2132430218 @default.
• W2133361341 cites W2141393682 @default.
• W2133361341 cites W2152521795 @default.
• W2133361341 cites W2152589229 @default.
• W2133361341 cites W2152984720 @default.
• W2133361341 cites W2159248478 @default.
• W2133361341 cites W2161252246 @default.
• W2133361341 cites W2164060627 @default.
• W2133361341 cites W2166920557 @default.
• W2133361341 cites W2168419545 @default.
• W2133361341 cites W246319838 @default.
• W2133361341 doi "https://doi.org/10.1093/hmg/ddp324" @default.
• W2133361341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748891" @default.
• W2133361341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19620182" @default.
• W2133361341 hasPublicationYear "2009" @default.
• W2133361341 type Work @default.
• W2133361341 sameAs 2133361341 @default.
• W2133361341 citedByCount "126" @default.
• W2133361341 countsByYear W21333613412012 @default.
• W2133361341 countsByYear W21333613412013 @default.
• W2133361341 countsByYear W21333613412014 @default.
• W2133361341 countsByYear W21333613412015 @default.
• W2133361341 countsByYear W21333613412016 @default.
• W2133361341 countsByYear W21333613412017 @default.
• W2133361341 countsByYear W21333613412018 @default.
• W2133361341 countsByYear W21333613412019 @default.
• W2133361341 countsByYear W21333613412020 @default.
• W2133361341 countsByYear W21333613412021 @default.
• W2133361341 countsByYear W21333613412022 @default.
• W2133361341 countsByYear W21333613412023 @default.
• W2133361341 crossrefType "journal-article" @default.
• W2133361341 hasAuthorship W2133361341A5009267002 @default.
• W2133361341 hasAuthorship W2133361341A5035887146 @default.
• W2133361341 hasAuthorship W2133361341A5036804333 @default.
• W2133361341 hasAuthorship W2133361341A5043458784 @default.
• W2133361341 hasAuthorship W2133361341A5049886632 @default.
• W2133361341 hasAuthorship W2133361341A5056838899 @default.
• W2133361341 hasAuthorship W2133361341A5089695450 @default.
• W2133361341 hasAuthorship W2133361341A5089747405 @default.
• W2133361341 hasAuthorship W2133361341A5091405504 @default.
• W2133361341 hasBestOaLocation W21333613412 @default.
• W2133361341 hasConcept C102747710 @default.
• W2133361341 hasConcept C104317684 @default.
• W2133361341 hasConcept C127561419 @default.
• W2133361341 hasConcept C127716648 @default.
• W2133361341 hasConcept C170493617 @default.
• W2133361341 hasConcept C2780395223 @default.
• W2133361341 hasConcept C28005876 @default.

• next