Matches in SemOpenAlex for { <https://semopenalex.org/work/W2133363442> ?p ?o ?g. }
- W2133363442 abstract "Phenotypic and target-based approaches represent two principal strategies for identifying new bioactive compounds. In this review, differences between these approaches, as well as strengths and limitations thereof, are described by examples from the therapeutic area of Alzheimer's disease. Some of the central mechanisms of the disease that today are targets of screening campaigns are described. These mechanisms include acetylcholinesterase inhibition, amyloid-based approaches, and oxidative stress. Examples of assays using natural products, either as isolated pure compounds, unpurified or partially purified extracts, are given for each mechanism. Further, the article presents and discusses the pros and cons of both target-based and phenotypic approaches for the chosen mechanisms. In most cases, a thoroughly biology-driven selection of the used assays can be recommended, especially when taking into account the complexity of the disease in question. However, target-based assays also have their justification as long as there is an awareness of what the assay read-out stands for. A clear recommendation is thus for every researcher to critically consider the aim of their bioactivity screening efforts and to adopt the screening strategies most appropriate for the goals set." @default.
- W2133363442 created "2016-06-24" @default.
- W2133363442 creator A5030800483 @default.
- W2133363442 date "2014-09-15" @default.
- W2133363442 modified "2023-09-26" @default.
- W2133363442 title "Assay Suitability for Natural Product Screening: Searching for Leads to Fight Alzheimerʼs Disease" @default.
- W2133363442 cites W1500036797 @default.
- W2133363442 cites W1503053736 @default.
- W2133363442 cites W1558022610 @default.
- W2133363442 cites W1576387485 @default.
- W2133363442 cites W176570333 @default.
- W2133363442 cites W1854324009 @default.
- W2133363442 cites W187210528 @default.
- W2133363442 cites W1964117773 @default.
- W2133363442 cites W1965694039 @default.
- W2133363442 cites W1967774489 @default.
- W2133363442 cites W1968772925 @default.
- W2133363442 cites W1969024078 @default.
- W2133363442 cites W1969793439 @default.
- W2133363442 cites W1970625741 @default.
- W2133363442 cites W1971048984 @default.
- W2133363442 cites W1971527053 @default.
- W2133363442 cites W1971885024 @default.
- W2133363442 cites W1972498735 @default.
- W2133363442 cites W1974715712 @default.
- W2133363442 cites W1974880827 @default.
- W2133363442 cites W1977570151 @default.
- W2133363442 cites W1982728268 @default.
- W2133363442 cites W1984587014 @default.
- W2133363442 cites W1987584317 @default.
- W2133363442 cites W1991994462 @default.
- W2133363442 cites W1999389082 @default.
- W2133363442 cites W2001995688 @default.
- W2133363442 cites W2003977124 @default.
- W2133363442 cites W2005576834 @default.
- W2133363442 cites W2008456822 @default.
- W2133363442 cites W2012327371 @default.
- W2133363442 cites W2014886338 @default.
- W2133363442 cites W2015526152 @default.
- W2133363442 cites W2016036842 @default.
- W2133363442 cites W2017976401 @default.
- W2133363442 cites W2026367326 @default.
- W2133363442 cites W2038113278 @default.
- W2133363442 cites W2038930719 @default.
- W2133363442 cites W2042600422 @default.
- W2133363442 cites W2046847750 @default.
- W2133363442 cites W2047701750 @default.
- W2133363442 cites W2047826130 @default.
- W2133363442 cites W2048322642 @default.
- W2133363442 cites W2052214665 @default.
- W2133363442 cites W2052346720 @default.
- W2133363442 cites W2052541369 @default.
- W2133363442 cites W2056947889 @default.
- W2133363442 cites W2060288971 @default.
- W2133363442 cites W2066914471 @default.
- W2133363442 cites W2066974786 @default.
- W2133363442 cites W2068042361 @default.
- W2133363442 cites W2068057673 @default.
- W2133363442 cites W2069539943 @default.
- W2133363442 cites W2071308173 @default.
- W2133363442 cites W2073743345 @default.
- W2133363442 cites W2076107018 @default.
- W2133363442 cites W2079977910 @default.
- W2133363442 cites W2080084871 @default.
- W2133363442 cites W2080796087 @default.
- W2133363442 cites W2087451417 @default.
- W2133363442 cites W2087467679 @default.
- W2133363442 cites W2088343957 @default.
- W2133363442 cites W2088935155 @default.
- W2133363442 cites W2091019399 @default.
- W2133363442 cites W2095378708 @default.
- W2133363442 cites W2096457412 @default.
- W2133363442 cites W2097391583 @default.
- W2133363442 cites W2103440561 @default.
- W2133363442 cites W2104227586 @default.
- W2133363442 cites W2115885329 @default.
- W2133363442 cites W2117077181 @default.
- W2133363442 cites W2119334175 @default.
- W2133363442 cites W2120293965 @default.
- W2133363442 cites W2129267808 @default.
- W2133363442 cites W2132815274 @default.
- W2133363442 cites W2134139278 @default.
- W2133363442 cites W2137124195 @default.
- W2133363442 cites W2137338838 @default.
- W2133363442 cites W2144135498 @default.
- W2133363442 cites W2148945876 @default.
- W2133363442 cites W2154538627 @default.
- W2133363442 cites W2160799179 @default.
- W2133363442 cites W2178572083 @default.
- W2133363442 cites W2265483816 @default.
- W2133363442 cites W2402973644 @default.
- W2133363442 cites W2405724104 @default.
- W2133363442 cites W3024630521 @default.
- W2133363442 doi "https://doi.org/10.1055/s-0034-1383063" @default.
- W2133363442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25221979" @default.
- W2133363442 hasPublicationYear "2014" @default.
- W2133363442 type Work @default.
- W2133363442 sameAs 2133363442 @default.
- W2133363442 citedByCount "4" @default.
- W2133363442 countsByYear W21333634422016 @default.