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• W2133377110 abstract "Plant RNA Pol V is involved in the RNA-directed DNA-methylation pathway that leads to heterochromatic silencing at some endogenous loci. Now the genomic regions targeted by Pol V in Arabidopsis thaliana are determined by ChIP-seq analyses revealing Pol V's enrichment at evolutionarily recent transposons. The plant-specific DNA-dependent RNA polymerase V (Pol V) evolved from Pol II to function in an RNA-directed DNA methylation pathway. Here, we have identified targets of Pol V in Arabidopsis thaliana on a genome-wide scale using ChIP-seq of NRPE1, the largest catalytic subunit of Pol V. We found that Pol V is enriched at promoters and evolutionarily recent transposons. This localization pattern is highly correlated with Pol V–dependent DNA methylation and small RNA accumulation. We also show that genome-wide chromatin association of Pol V is dependent on all members of a putative chromatin-remodeling complex termed DDR. Our study presents a genome-wide view of Pol V occupancy and sheds light on the mechanistic basis of Pol V localization. Furthermore, these findings suggest a role for Pol V and RNA-directed DNA methylation in genome surveillance and in responding to genome evolution." @default.
• W2133377110 created "2016-06-24" @default.
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• W2133377110 date "2012-08-05" @default.
• W2133377110 modified "2023-10-06" @default.
• W2133377110 title "DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons" @default.
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• W2133377110 doi "https://doi.org/10.1038/nsmb.2354" @default.
• W2133377110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3443314" @default.
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